NFATC1 and TUBA1A

Number of citations of the paper that reports this interaction (PMID 21278340)
0

Data Source:
BioGRID (pull down)

		NFATC1	TUBA1A
Gene Name		nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	tubulin, alpha 1a
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Nucleus Cytosol Microtubule Cytoplasmic Microtubule Cytoplasmic Ribonucleoprotein Granule Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding FK506 Binding Transcription Regulatory Region DNA Binding Mitogen-activated Protein Kinase P38 Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Calcium Ion Transport Heart Development Osteoclast Differentiation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Organelle Organization Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization Cell Division
Pathways		Ca2+ pathway Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling	Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane L1CAM interactions G2/M Transition Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Albendazole Vinblastine Mebendazole Epothilone D Epothilone B 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		16 interactors: EGR1 EGR2 EP300 GNB2L1 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA SPI1 TUBA1A YWHAQ	53 interactors: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CLIP1 CNP CXCR1 CYLD DAG1 DUSP23 EGFR GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LRRK2 MAP2 MAPK6 MAPRE1 MAX MYC NFATC1 NUDT3 PAFAH1B1 PFDN1 PLA2G7 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPG20 STARD13 SYK TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		4772	7846
HPRD ID		02729	03959
Ensembl ID		ENSG00000131196	ENSG00000167552
Uniprot IDs		A8K9C6 B4DER8 F5H4S8 O95644	Q71U36
PDB IDs		1A66 1NFA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Apoptotic Process Programmed Cell Death Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Response To Peptide Peptidyl-lysine Modification Negative Regulation Of Gene Expression Response To Insulin Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription N-terminal Peptidyl-lysine Acetylation Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Rhythmic Process Regulation Of RNA Metabolic Process Skeletal Muscle Tissue Development Leukocyte Differentiation Skeletal Muscle Organ Development Immune System Process Regulation Of Protein Metabolic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Histone Modification Regulation Of Signaling Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Protein Localization Innate Immune Response	Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Communication Cell Death Death Intracellular Signal Transduction Signaling Programmed Cell Death Response To Stimulus Response To Organic Substance Positive Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Response To Stress Regulation Of Cellular Component Organization Negative Regulation Of Phosphorylation Apoptotic Process Developmental Process Cell Cycle Regulation Of Intracellular Transport System Development Regulation Of Intracellular Signal Transduction Defense Response Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Organic Substance Cellular Process Negative Regulation Of Intracellular Signal Transduction Locomotion Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Immune System Process Anatomical Structure Development Signal Transduction Regulation Of Phosphorylation Regulation Of Cell Death Immune Response-regulating Signaling Pathway Neuron Development Regulation Of Growth Nervous System Development Cell Differentiation Cell Development Regulation Of Kinase Activity Neuron Projection Morphogenesis Regulation Of Cellular Process Multicellular Organismal Development Innate Immune Response Cell Projection Morphogenesis Cell Migration
Tagcloud ?		124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting itgb1 killed leucocyte lewis luciferase micrornas mir osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr	brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread
Tagcloud (Difference) ?		124a aia ameliorated analogue ankle arthritis ccaat destruction freund hind histopathology incomplete injecting itgb1 killed leucocyte lewis luciferase micrornas mir osteoclasts prerequisites rankl raw264 rheumatoid rnas synoviocyte tartrate utr	brainstem calorimetry elucidate exerts feeding fret interactive interacts isothermal itc library neurodegeneration neurological screened se sec selenium selenocysteines selenoprotein selenoproteins selp terminus titration trace transporter tubulin verified widespread
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