NFATC1

Name	nuclear factor of activated T cells 1
Structure
Interactors	16 interactors: EGR1 EGR2 EP300 HDAC5 KAT2B KPNB1 MAPK14 PARP1 PIAS1 PIM1 PPP3R1 PRKCA RACK1 SPI1 TUBA1A YWHAQ
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding FK506 Binding Protein Phosphatase 2B Binding Mitogen-activated Protein Kinase P38 Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs	Pseudoephedrine
GWAS	Appendicular lean mass ( 33097823 ) Blood urea nitrogen levels ( 31152163 29403010 ) Body size at age 10 ( 32376654 ) Cerebrospinal P-tau181p levels ( 28247064 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic kidney disease ( 31152163 29124443 ) Creatinine levels ( 29124443 31015462 29403010 ) Crohn's disease ( 26192919 ) Estimated glomerular filtration rate ( 29124443 31015462 31152163 31451708 29779033 30604766 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Feeling hurt ( 29500382 ) Femoral neck bone mineral density ( 32239398 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) Glomerular filtration rate ( 29403010 27588450 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 31562340 ) Hyperuricemia ( 29124443 ) Inflammatory bowel disease ( 26192919 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 32888494 27863252 ) Medication use (drugs affecting bone structure and mineralization) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Neonatal white matter microstructure ( 33009551 ) Neutrophil percentage of white cells ( 32888494 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 ) Refractive error ( 32231278 ) Serum alkaline phosphatase levels ( 33547301 ) Serum creatinine levels ( 29779033 ) Waist circumference adjusted for body mass index ( 34021172 ) Working memory ( 31598132 )
Entrez ID	4772
HPRD ID	02729
Ensembl ID	ENSG00000131196
Uniprot IDs	A8K9C6 B4DER8 F5H4S8 O95644
PDB IDs	1A66 1NFA 5SVE
GO Terms Enriched among Interactors ?	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Enzyme Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic Response To Peptide Hormone Response To Insulin Cellular Response To Oxygen-containing Compound Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA-binding Transcription Factor Binding Programmed Cell Death Response To Hormone Positive Regulation Of Developmental Process Cell Death RNA Polymerase II-specific DNA-binding Transcription Factor Binding Leukocyte Differentiation Regulation Of Developmental Process Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Response To Radiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process N-terminal Peptidyl-lysine Acetylation Regulation Of Cell Differentiation Protein-containing Complex Positive Regulation Of Intracellular Signal Transduction Chromatin Binding Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Metabolic Process