NEDD9 and BCAR3

Number of citations of the paper that reports this interaction (PMID 12517963)
18

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		NEDD9	BCAR3
Gene Name		neural precursor cell expressed, developmentally down-regulated 9	breast cancer anti-estrogen resistance 3
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Golgi Apparatus Spindle Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cytoskeleton Organization Mitotic Nuclear Division Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Growth Actin Filament Bundle Assembly Cell Division	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of GTPase Activity
Pathways
Drugs
Diseases
GWAS		HIV-1 susceptibility ( 22174851)
Protein-Protein Interactions		40 interactors: ABL1 APP BANP BCAR1 BCAR3 CDH1 CHAT CRK CRKL DIMT1 ELSPBP1 FYN ID2 ITCH LCK LYN MICAL1 NAB2 NCK1 NFKBIA NOTCH3 PIK3CA PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 TCF3 TRIM27 TRIP6 ZYX	6 interactors: APP ERBB2 ERBB3 KPNA1 NEDD9 RPRD1A
Entrez ID		4739	8412
HPRD ID		11888	05268
Ensembl ID		ENSG00000111859	ENSG00000137936
Uniprot IDs		Q14511	B3KNL6 B3KP06 O75815
PDB IDs		2L81	3T6A
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Immune System Process Innate Immune Response Response To Organonitrogen Compound Cell Activation Regulation Of Signal Transduction Regulation Of Immune Response Signaling Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune System Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Regulation Of Metabolic Process Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune System Process Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Response To Organic Substance Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Defense Response	Phosphatidylinositol 3-kinase Signaling Neuromuscular Junction Development Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Neuron Death Cell Surface Receptor Signaling Pathway Peripheral Nervous System Development Wound Healing Regulation Of Growth Response To Wounding Synaptic Growth At Neuromuscular Junction Phosphatidylinositol-mediated Signaling Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Innate Immune Response Synapse Organization Glial Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Dephosphorylation Of RNA Polymerase II C-terminal Domain Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Gliogenesis Cell Death Death Regulation Of Protein Phosphorylation Axon Choice Point Recognition Positive Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Differentiation In Thymus Neuron Remodeling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Signal Transduction
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	adjuvant bcl2 cohorts dutch easily endpoint esr1 favorable implemented indicative mann menopausal naive nat1 ncoa1 pfs pgr predictive promise qpcr select setting signatures start stratify tamoxifen transcriptase univariate whitney
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 crmp1 folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	adjuvant bcl2 cohorts dutch easily esr1 favorable implemented indicative mann menopausal naive nat1 ncoa1 pfs pgr predictive promise qpcr select setting signatures start stratify tamoxifen transcriptase univariate whitney
Tagcloud (Intersection) ?		endpoint