NEDD9 and DIMT1

Number of citations of the paper that reports this interaction (PubMedID 9584194)
70

Data Source:
HPRD (two hybrid)

		NEDD9	DIMT1
Description		neural precursor cell expressed, developmentally down-regulated 9	DIM1 rRNA methyltransferase and ribosome maturation factor
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GO Annotations	Cellular Component	Spindle Pole Immunological Synapse Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Lamellipodium Ciliary Basal Body Cell Projection Anchoring Junction Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytosol Small-subunit Processome
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	RRNA (adenine-N6,N6-)-dimethyltransferase Activity RNA Binding Methyltransferase Activity Transferase Activity 18S RRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase Activity
	Biological Process	Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Learning Or Memory Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoclast Differentiation Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Cilium Disassembly Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization Positive Regulation Of Immunological Synapse Formation	RRNA Modification RRNA Processing RRNA Methylation Methylation Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing
Pathways			rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)
Interacting Genes		70 interacting genes: ABL1 ACTMAP ANKS1A APP AURKA BANP BCAR1 BCAR3 CDC42EP2 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 DOCK9 DPPA4 EEIG1 ELSPBP1 EXOSC8 FAM168B FOSB FYN FZR1 HOXA1 ID2 INCA1 ITCH KLHL20 KRT32 LCK LHX8 LYN MED19 MICAL1 NAB2 NBPF19 NCK1 NFKBIA NOTCH2NLA NOTCH3 PEX14 PIK3CA PIK3R3 PRAM1 PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 SNAPIN TBX19 TCF3 TFCP2 TRAF2 TRIM23 TRIM27 TRIP6 WWOX ZNF76 ZYX	4 interacting genes: APP CEBPA NEDD9 PRRC2B
Entrez ID		4739	27292
HPRD ID		11888	13676
Ensembl ID		ENSG00000111859	ENSG00000086189
Uniprot IDs		A0A087WUD2 Q14511	A0A0C4DGB1 A8K9K8 Q9UNQ2
PDB IDs		2L81 5X3S	1ZQ9 6W6C 6W6F 7MQA 7WTS
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Leukocyte Activation Cell Activation Positive Regulation Of Metabolic Process T Cell Receptor Signaling Pathway Cell Migration Response To Transforming Growth Factor Beta Signal Complex Assembly Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Immune Response Lymphocyte Activation Intracellular Signaling Cassette Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intracellular Signal Transduction Endothelin Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Integrin-mediated Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Nucleus Signal Transduction Regulation Of Metabolic Process	Regulation Of Dendritic Spine Maintenance Learning Or Memory Cognition Positive Regulation Of Lymphocyte Migration Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Cell Activation Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Lymphocyte Migration Positive Regulation Of Leukocyte Chemotaxis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Notch Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Postsynapse Organization Lipoprotein Particle Positive Regulation Of Cell Differentiation Memory Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Nervous System Process CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Positive Regulation Of Immunological Synapse Formation Positive Regulation Of Proteolysis Positive Regulation Of Immune System Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Maturation Regulation Of Chemotaxis Positive Regulation Of Protein Catabolic Process Cellular Response To Norepinephrine Stimulus
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