NEDD9 and SH2D3C

Number of citations: 0 (PubMedID 10692442)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo, in vitro)

		NEDD9	SH2D3C
Name		neural precursor cell expressed, developmentally down-regulated 9	SH2 domain containing 3C
Structure
GO Annotations	Cellular Component	Spindle Pole Immunological Synapse Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Lamellipodium Ciliary Basal Body Cell Projection Anchoring Junction Mitotic Spindle	Cytoplasm Cytosol Plasma Membrane Membrane Axon Ruffle Membrane Cell Projection
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Learning Or Memory Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoclast Differentiation Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Cilium Disassembly Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization Positive Regulation Of Immunological Synapse Formation	JNK Cascade Small GTPase-mediated Signal Transduction
GWAS		Childhood dental caries in permanent teeth ( 29931343 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) HIV-1 susceptibility ( 22174851 ) Macular thickness ( 30535121 ) Prostate cancer ( 25217961 ) Small cell lung carcinoma ( 28604730 )	Basophil percentage of white cells ( 32888494 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of white cells ( 32888494 )
Interacting Genes		70 interacting genes: ABL1 ACTMAP ANKS1A APP AURKA BANP BCAR1 BCAR3 CDC42EP2 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 DOCK9 DPPA4 EEIG1 ELSPBP1 EXOSC8 FAM168B FOSB FYN FZR1 HOXA1 ID2 INCA1 ITCH KLHL20 KRT32 LCK LHX8 LYN MED19 MICAL1 NAB2 NBPF19 NCK1 NFKBIA NOTCH2NLA NOTCH3 PEX14 PIK3CA PIK3R3 PRAM1 PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 SNAPIN TBX19 TCF3 TFCP2 TRAF2 TRIM23 TRIM27 TRIP6 WWOX ZNF76 ZYX	16 interacting genes: AR BCAR1 CARD11 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 KIT MAPK1 MET NEDD9 PTK2B SNCAIP SRC
Entrez ID		4739	10044
HPRD ID		11888	05284
Ensembl ID		ENSG00000111859	ENSG00000095370
Uniprot IDs		A0A087WUD2 Q14511	B4DG32 Q8N5H7
PDB IDs		2L81 5X3S	3T6G
GO Terms Enriched among Interactors		Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Leukocyte Activation Cell Activation Positive Regulation Of Metabolic Process T Cell Receptor Signaling Pathway Cell Migration Response To Transforming Growth Factor Beta Signal Complex Assembly Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Immune Response Lymphocyte Activation Intracellular Signaling Cassette Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intracellular Signal Transduction Endothelin Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Integrin-mediated Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Nucleus Signal Transduction Regulation Of Metabolic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity ERBB Signaling Pathway ERBB2 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Locomotion Positive Regulation Of Cell Population Proliferation Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Migration Basal Plasma Membrane Positive Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Protein Phosphorylation Receptor Complex Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphorylation Negative Regulation Of Programmed Cell Death Cell Migration Positive Regulation Of Metabolic Process Signal Transduction ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling ATP Binding Plasma Membrane Response To Epidermal Growth Factor Cell Motility