TTN and MYBPC3

Number of citations of the paper that reports this interaction (PMID 8631348)
58

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		TTN	MYBPC3
Gene Name		titin	myosin binding protein C, cardiac
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere A Band
	Molecular Function	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity	ATPase Activator Activity Actin Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Regulation Of Heart Rate Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Muscle Filament Sliding Myosin Filament Assembly Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Striated Muscle Contraction
Drugs
Diseases
GWAS		Breast size ( 22747683) QT interval ( 20031603)
Protein-Protein Interactions		29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2	7 interactors: CAPN1 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN
Entrez ID		7273	4607
HPRD ID		01787	02980
Ensembl ID		ENSG00000155657	ENSG00000134571
Uniprot IDs		Q7Z3B7 Q8WZ42	A5YM48 Q14896
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3	1GXE 1PD6 2AVG 2K1M 2V6H 3CX2
Enriched GO Terms of Interacting Partners?		Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation	Actin Filament-based Movement Actomyosin Structure Organization Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Platelet Activation Uropod Organization Establishment Of Meiotic Spindle Localization Myosin Filament Assembly Establishment Of T Cell Polarity Respiratory Burst Involved In Defense Response Skeletal Muscle Atrophy Response To Yeast Muscle Contraction Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Killing By Host Of Symbiont Cells Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Muscle System Process Skeletal Muscle Adaptation Hydrogen Peroxide Biosynthetic Process Meiotic Spindle Organization Muscle Cell Differentiation Respiratory Burst Receptor Catabolic Process Negative Regulation Of Smooth Muscle Contraction Adult Heart Development Superoxide Anion Generation Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Neutrophil Mediated Immunity Blood Coagulation Hemostasis Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Cardiac Myofibril Assembly Killing Of Cells Of Other Organism Proteolysis Cardiac Muscle Hypertrophy Mitotic Chromosome Condensation
Tagcloud ?		amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl	11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants
Tagcloud (Difference) ?		amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl	11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants
Tagcloud (Intersection) ?