TTN and RPL12

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TTN	RPL12
Description		titin	ribosomal protein L12
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Nucleus Cytoplasm Cytosol Striated Muscle Thin Filament Actin Cytoskeleton Z Disc M Band I Band Protein-containing Complex Extracellular Exosome Titin-telethonin Complex	Cytoplasm Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Kinase Activity Transferase Activity Protein Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding
	Biological Process	Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Sarcomerogenesis Positive Regulation Of Protein Secretion Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction	Cytoplasmic Translation Translation
Pathways		Platelet degranulation Striated Muscle Contraction	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases		Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM)
GWAS		Atrial fibrillation ( 30061737 29892015 29290336) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 32382064 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass ( 33495596) PR interval ( 32439900 30046033) QT interval ( 24952745 20031603 29874175 29213071) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Sick sinus syndrome ( 33580673) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		83 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 ENO1 ENO3 EXOSC10 FBXO32 FHL1 FHL2 FILNC1 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAP1LC3A MAP1LC3B MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 STUB1 TAB2 TCAP TRIM54 TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 USP7 VAV2	11 interacting genes: APP CBX1 DUX4 FNDC3B IPO11 OGT OR10G4 PAXIP1 PTEN TTN UBC
Entrez ID		7273	6136
HPRD ID		01787	01603
Ensembl ID		ENSG00000155657	ENSG00000197958
Uniprot IDs		A0A0A0MRA3 Q8WZ42	P30050
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6FWX 6H4L 6HCI 6I0Y 6SDB 6YGN 7AHS 7NIP 8BNQ 8BVO 8BW6 8BXR 8G4L 8OIY 8OMW 8OQ9 8ORL 8OS3 8OSD 8OT5 8OTY 8OVU 8P35	4V6X 5A8L 5AJ0 6OLG 6ZM7 6ZME 6ZMI 6ZMO 7VB2 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8G5Z 8G60 8G6J 8IDT 8IDY 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8K2C 8RL2 8UKB 8XSX 8XSY 8XSZ 8YOO 8YOP
Enriched GO Terms of Interacting Partners?		Z Disc Structural Constituent Of Muscle M Band Titin Binding Sarcomere Organization Actomyosin Structure Organization Actin Cytoskeleton Organization Sarcomere Actin Filament-based Process Cytoskeleton Organization Cytoplasm Cytosol Myosin Filament I Band Muscle Structure Development Muscle Organ Development Actin Binding Actin Cytoskeleton Pseudopodium Transmembrane Transporter Binding Muscle Cell Development Organelle Organization Myofibril Focal Adhesion Protein Binding Actin Filament Binding Integrin Binding Developmental Process Actin Filament Stress Fiber Muscle System Process Cytoskeleton Metal Ion Binding Regulation Of Intracellular Signal Transduction Muscle Contraction Regulation Of Cellular Component Organization Cellular Response To Nitrogen Starvation Cell Adhesion Unfolded Protein Binding Regulation Of Muscle Contraction Titin Z Domain Binding Striated Muscle Cell Development Regulation Of Muscle System Process Contractile Muscle Fiber Protein K63-linked Ubiquitination Cell-substrate Junction Assembly Phosphatidylethanolamine Binding Cell-substrate Junction Organization Autophagosome Protein Folding	Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Neuron Projection Organization Enzyme Binding Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Vesicle Clustering Membraneless Organelle Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Apoptotic Process Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Chromatin Organization Positive Regulation Of Protein Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Protein O-acetylglucosaminyltransferase Activity Chorion Development Positive Regulation Of RNA Biosynthetic Process
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