TTN and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TTN	ACTN4
Description		titin	actinin alpha 4
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Nucleus Cytoplasm Cytosol Striated Muscle Thin Filament Actin Cytoskeleton Z Disc M Band I Band Protein-containing Complex Extracellular Exosome Titin-telethonin Complex	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Kinase Activity Transferase Activity Protein Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Sarcomerogenesis Positive Regulation Of Protein Secretion Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Platelet degranulation Striated Muscle Contraction	Platelet degranulation Nephrin family interactions
Drugs
Diseases		Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM)	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Atrial fibrillation ( 30061737 29892015 29290336) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 32382064 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass ( 33495596) PR interval ( 32439900 30046033) QT interval ( 24952745 20031603 29874175 29213071) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Sick sinus syndrome ( 33580673) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		83 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 ENO1 ENO3 EXOSC10 FBXO32 FHL1 FHL2 FILNC1 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAP1LC3A MAP1LC3B MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 STUB1 TAB2 TCAP TRIM54 TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 USP7 VAV2	60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		7273	81
HPRD ID		01787	05222
Ensembl ID		ENSG00000155657	ENSG00000130402
Uniprot IDs		A0A0A0MRA3 Q8WZ42	A0A0S2Z3G9 F5GXS2 H7C144 O43707
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6FWX 6H4L 6HCI 6I0Y 6SDB 6YGN 7AHS 7NIP 8BNQ 8BVO 8BW6 8BXR 8G4L 8OIY 8OMW 8OQ9 8ORL 8OS3 8OSD 8OT5 8OTY 8OVU 8P35	1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?		Z Disc Structural Constituent Of Muscle M Band Titin Binding Sarcomere Organization Actomyosin Structure Organization Actin Cytoskeleton Organization Sarcomere Actin Filament-based Process Cytoskeleton Organization Cytoplasm Cytosol Myosin Filament I Band Muscle Structure Development Muscle Organ Development Actin Binding Actin Cytoskeleton Pseudopodium Transmembrane Transporter Binding Muscle Cell Development Organelle Organization Myofibril Focal Adhesion Protein Binding Actin Filament Binding Integrin Binding Developmental Process Actin Filament Stress Fiber Muscle System Process Cytoskeleton Metal Ion Binding Regulation Of Intracellular Signal Transduction Muscle Contraction Regulation Of Cellular Component Organization Cellular Response To Nitrogen Starvation Cell Adhesion Unfolded Protein Binding Regulation Of Muscle Contraction Titin Z Domain Binding Striated Muscle Cell Development Regulation Of Muscle System Process Contractile Muscle Fiber Protein K63-linked Ubiquitination Cell-substrate Junction Assembly Phosphatidylethanolamine Binding Cell-substrate Junction Organization Autophagosome Protein Folding	Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process
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