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NCF4 and NCF2
Number of citations of the paper that reports this interaction (PubMedID
11796733
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
NCF4
NCF2
Description
neutrophil cytosolic factor 4
neutrophil cytosolic factor 2
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Phagolysosome
NADPH Oxidase Complex
Acrosomal Vesicle
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Phagolysosome
NADPH Oxidase Complex
Molecular Function
Protein Binding
Lipid Binding
Superoxide-generating NADPH Oxidase Activator Activity
Phosphatidylinositol-3-phosphate Binding
Phosphatidylinositol Binding
Protein Binding
Electron Transfer Activity
Superoxide-generating NAD(P)H Oxidase Activity
Superoxide-generating NADPH Oxidase Activator Activity
Small GTPase Binding
Biological Process
Phagocytosis
Superoxide Anion Generation
Respiratory Burst
Superoxide Metabolic Process
Phagocytosis
Cellular Defense Response
Superoxide Anion Generation
Innate Immune Response
Respiratory Burst
Pathways
ROS and RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
RAC1 GTPase cycle
RAC2 GTPase cycle
RAC3 GTPase cycle
ROS and RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
RAC1 GTPase cycle
RAC2 GTPase cycle
RAC3 GTPase cycle
Drugs
Dextromethorphan
Dextromethorphan
Diseases
Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Allergic disease (asthma, hay fever or eczema) (
29679657
)
Asthma (
32296059
)
Atopic dermatitis (
22197932
)
Crohn's disease (
28067908
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Inflammatory bowel disease (
27569725
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Multiple sclerosis (
24076602
31604244
)
Multiple sclerosis and triglyceride levels (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Sum eosinophil basophil counts (
27863252
)
Celiac disease (
31591516
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Systemic lupus erythematosus (
19838195
26502338
26606652
27399966
28714469
33272962
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Interacting Genes
11 interacting genes:
CORO1A
CRYAA
CYBA
CYBB
MSN
NCF1
NCF2
PRKCD
PRKDC
TXN
XRCC6
15 interacting genes:
AKT1
CDC42
CYBA
CYBB
GOLGA2
KIFAP3
NCF1
NCF4
PRDX6
PRKDC
RAC1
RAC2
S100A8
S100A9
SYTL1
Entrez ID
4689
4688
HPRD ID
03289
01991
Ensembl ID
ENSG00000100365
ENSG00000116701
Uniprot IDs
A0A494BZS1
Q15080
A0A0S2Z457
A0A8V8TMB9
P19878
PDB IDs
1H6H
1OEY
1W6X
1W70
1Z9Q
2DYB
1E96
1HH8
1K4U
1OEY
1WM5
2DMO
8WEJ
Enriched GO Terms of Interacting Partners
?
Superoxide-generating NAD(P)H Oxidase Activity
NADPH Oxidase Complex
Respiratory Burst
Superoxide Anion Generation
Hydrogen Peroxide Metabolic Process
Reactive Oxygen Species Metabolic Process
Superoxide Metabolic Process
Innate Immune Response
Hydrogen Peroxide Biosynthetic Process
Response To Other Organism
Electron Transfer Activity
Immune Response
Defense Response To Symbiont
Defense Response To Other Organism
Immune System Process
Response To Radiation
Reactive Oxygen Species Biosynthetic Process
Response To External Biotic Stimulus
Defense Response
Response To Angiotensin
Cellular Response To L-glutamine
Phagolysosome
DNA-dependent Protein Kinase Complex
Response To Gamma Radiation
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Response To Stress
Nonhomologous End Joining Complex
Regulation Of Immune System Process
Superoxide-generating NADPH Oxidase Activator Activity
Phagocytic Vesicle Membrane
Regulation Of Intracellular Transport
Response To Peptide Hormone
Immunological Synapse Formation
Cellular Response To Angiotensin
Lymphocyte Proliferation
Response To Aldosterone
Cytoplasm
Mononuclear Cell Proliferation
Perinuclear Endoplasmic Reticulum
Positive Regulation Of Superoxide Anion Generation
Regulation Of Superoxide Anion Generation
Leukocyte Proliferation
Peptidyl-threonine Phosphorylation
Response To Ionizing Radiation
Regulation Of Defense Response
Regulation Of Smooth Muscle Cell Proliferation
Cellular Response To Oxygen-containing Compound
Regulation Of Innate Immune Response
Cellular Response To Gamma Radiation
Lymphocyte Activation
NADPH Oxidase Complex
Respiratory Burst
Superoxide Anion Generation
Superoxide Metabolic Process
Reactive Oxygen Species Metabolic Process
Regulation Of Respiratory Burst
Hydrogen Peroxide Metabolic Process
Hydrogen Peroxide Biosynthetic Process
Superoxide-generating NAD(P)H Oxidase Activity
Leukocyte Aggregation
Inflammatory Response
Positive Regulation Of Cell Growth
Reactive Oxygen Species Biosynthetic Process
Calprotectin Complex
Neutrophil Aggregation
Regulation Of Innate Immune Response
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Growth
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Positive Regulation Of Lamellipodium Organization
Cellular Response To L-glutamine
Phagolysosome
Peptidyl-cysteine S-nitrosylation
Regulation Of Lamellipodium Assembly
Regulation Of Toll-like Receptor Signaling Pathway
Defense Response
Erythrocyte Enucleation
Toll-like Receptor 4 Binding
Positive Regulation Of Cell Projection Organization
Innate Immune Response
Arachidonate Binding
Regulation Of Lamellipodium Organization
Defense Response To Fungus
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Leukocyte Cell-cell Adhesion
Regulation Of Cell Growth
Electron Transfer Activity
Regulation Of Immune System Process
Autocrine Signaling
Response To Fungus
Regulation Of Respiratory Burst Involved In Inflammatory Response
Membrane
Defense Response To Symbiont
Superoxide-generating NADPH Oxidase Activator Activity
Defense Response To Other Organism
Protein Kinase Binding
Response To Ketone
Positive Regulation Of Defense Response
Thioesterase Binding
Chronic Inflammatory Response
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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