NCF4

Description		neutrophil cytosolic factor 4
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Phagocytosis Superoxide Anion Generation Respiratory Burst
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		11 interacting genes: CORO1A CRYAA CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		4689
HPRD ID		03289
Ensembl ID		ENSG00000100365
Uniprot IDs		A0A494BZS1 Q15080
PDB IDs		1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?		Superoxide-generating NAD(P)H Oxidase Activity NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide Metabolic Process Innate Immune Response Hydrogen Peroxide Biosynthetic Process Response To Other Organism Electron Transfer Activity Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Radiation Reactive Oxygen Species Biosynthetic Process Response To External Biotic Stimulus Defense Response Response To Angiotensin Cellular Response To L-glutamine Phagolysosome DNA-dependent Protein Kinase Complex Response To Gamma Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Response To Stress Nonhomologous End Joining Complex Regulation Of Immune System Process Superoxide-generating NADPH Oxidase Activator Activity Phagocytic Vesicle Membrane Regulation Of Intracellular Transport Response To Peptide Hormone Immunological Synapse Formation Cellular Response To Angiotensin Lymphocyte Proliferation Response To Aldosterone Cytoplasm Mononuclear Cell Proliferation Perinuclear Endoplasmic Reticulum Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Leukocyte Proliferation Peptidyl-threonine Phosphorylation Response To Ionizing Radiation Regulation Of Defense Response Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Oxygen-containing Compound Regulation Of Innate Immune Response Cellular Response To Gamma Radiation Lymphocyte Activation
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