NCF4 and CYBB

Number of citations of the paper that reports this interaction (PubMedID 11893732)
0

Data Source:
HPRD (in vivo)

		NCF4	CYBB
Description		neutrophil cytosolic factor 4	cytochrome b-245 beta chain
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Dendrite Phagocytic Vesicle Membrane Monoatomic Ion Channel Complex Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Phagocytic Vesicle Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protein Binding Lipid Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	Protein Binding Electron Transfer Activity NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Voltage-gated Proton Channel Activity Metal Ion Binding Protein Heterodimerization Activity Flavin Adenine Dinucleotide Binding Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor NADPH Binding FAD Binding Superoxide-generating NADPH Oxidase Activity
	Biological Process	Phagocytosis Superoxide Anion Generation Respiratory Burst	Superoxide Metabolic Process Monoatomic Ion Transport Defense Response Inflammatory Response Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Tumor Necrosis Factor Production Monoatomic Ion Transmembrane Transport Superoxide Anion Generation Innate Immune Response Response To Ethanol Respiratory Burst Positive Regulation Of Angiogenesis Hydrogen Peroxide Biosynthetic Process Cellular Response To Cadmium Ion Cellular Response To Ethanol Cellular Response To Hypoxia Hypoxia-inducible Factor-1alpha Signaling Pathway Response To Aldosterone Cellular Response To L-glutamine Response To Angiotensin
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		11 interacting genes: CORO1A CRYAA CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6	7 interacting genes: ACTG1 CYBA CYBC1 IQGAP1 NCF2 NCF4 RAC1
Entrez ID		4689	1536
HPRD ID		03289	02382
Ensembl ID		ENSG00000100365	ENSG00000165168
Uniprot IDs		A0A494BZS1 Q15080	A0A0S2Z3S6 P04839
PDB IDs		1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB	3A1F 7U8G 8GZ3 8KEI 8WEJ 8X2L
Enriched GO Terms of Interacting Partners?		Superoxide-generating NAD(P)H Oxidase Activity NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Reactive Oxygen Species Metabolic Process Superoxide Metabolic Process Innate Immune Response Hydrogen Peroxide Biosynthetic Process Response To Other Organism Electron Transfer Activity Immune Response Defense Response To Symbiont Defense Response To Other Organism Immune System Process Response To Radiation Reactive Oxygen Species Biosynthetic Process Response To External Biotic Stimulus Defense Response Response To Angiotensin Cellular Response To L-glutamine Phagolysosome DNA-dependent Protein Kinase Complex Response To Gamma Radiation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Response To Stress Nonhomologous End Joining Complex Regulation Of Immune System Process Superoxide-generating NADPH Oxidase Activator Activity Phagocytic Vesicle Membrane Regulation Of Intracellular Transport Response To Peptide Hormone Immunological Synapse Formation Cellular Response To Angiotensin Lymphocyte Proliferation Response To Aldosterone Cytoplasm Mononuclear Cell Proliferation Perinuclear Endoplasmic Reticulum Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Leukocyte Proliferation Peptidyl-threonine Phosphorylation Response To Ionizing Radiation Regulation Of Defense Response Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Oxygen-containing Compound Regulation Of Innate Immune Response Cellular Response To Gamma Radiation Lymphocyte Activation	Respiratory Burst NADPH Oxidase Complex Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Phagolysosome Actin Filament Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Focal Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Basal Body Patch Regulation Of Focal Adhesion Assembly Regulation Of Endocytosis Smooth Muscle Hypertrophy Negative Regulation Of Glomerular Filtration By Angiotensin Electron Transfer Activity Regulation Of Cell-substrate Junction Organization Protein Kinase Binding Regulation Of Stress Fiber Assembly Endocytosis Phagocytosis Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Cytoplasmic Ribonucleoprotein Granule Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Secretory Granule Membrane Cerebral Cortex GABAergic Interneuron Development Regulation Of Renal Output By Angiotensin Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Regulation Of Cell-matrix Adhesion Regulation Of Transepithelial Transport Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamine Regulation Of Reactive Oxygen Species Metabolic Process Response To External Biotic Stimulus Mitotic Spindle Astral Microtubule Actomyosin Contractile Ring Assembly Actin Filament Organization Respiratory Burst After Phagocytosis Dense Body Positive Regulation Of Mucus Secretion Defense Response Import Into Cell Regulation Of Ovarian Follicle Development Erythrocyte Enucleation
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