ATF3 and DOK5

Number of citations: 62 (PubMedID 25814554)
Data Source: BioGRID (two hybrid)

		ATF3	DOK5
Name		activating transcription factor 3	docking protein 5
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Golgi Apparatus Centrosome Nuclear Body Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex CHOP-ATF3 Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Regulation of PD-L1(CD274) transcription	RET signaling
Drugs		Pseudoephedrine	None
GWAS		Blood cell traits (multivariate analysis) ( 31080455 ) Cerebral amyloid deposition (PET imaging) ( 26252872 ) Coronary artery disease ( 29212778 ) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122 )	Celiac disease ( 23936387 ) Erectile dysfunction ( 30583798 ) Functional MRI ( 20215924 ) HDL cholesterol levels in HIV infection ( 33109212 )
Novel Interactors		1 novel interactors: NEK2	None recorded
Interacting Genes		50 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG MDM2 NFE2L2 NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I UBR1 UBR2 UBR5 ZNF212	20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ
Entrez ID		467	55816
HPRD ID		04395	16317
Ensembl ID		ENSG00000162772	ENSG00000101134
Uniprot IDs		P18847	Q9P104
PDB IDs		Not available	1J0W
GO Terms Enriched among Interactors		RNA Polymerase II Transcription Regulator Complex Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of RNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Promoter-specific Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Developmental Process DNA Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Developmental Process Intracellular Signaling Cassette Cellular Response To Stress Intracellular Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Axon Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Complex Neurotrophin Receptor Activity Neurotrophin Binding Insulin Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Kinase Activity Dendritic Spine Maintenance Action Potential Propagation Neuronal Action Potential Propagation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Insulin-like Growth Factor I Binding Insulin Receptor Substrate Binding Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Endosome Phosphatidylinositol 3-kinase Binding Myelination Axon Ensheathment Myelination In Peripheral Nervous System Learning Or Memory Positive Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Endosome Membrane Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Nervous System Process Protein Autophosphorylation Amyloid-beta Clearance Mechanoreceptor Differentiation Cognition Positive Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Cell Population Proliferation Neurotrophin Signaling Pathway Positive Regulation Of Locomotion