ATF3 and DBP

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ATF3	DBP
Description		activating transcription factor 3	D-box binding PAR bZIP transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Golgi Apparatus Centrosome Nuclear Body Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex CHOP-ATF3 Complex	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Liver Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Regulation of PD-L1(CD274) transcription	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs		Pseudoephedrine
Diseases
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Cerebral amyloid deposition (PET imaging) ( 26252872) Coronary artery disease ( 29212778) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122)	Bipolar disorder ( 21926972) Crohn's disease ( 23128233) Elevated serum carcinoembryonic antigen levels ( 24941225) Lymphocyte count ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		50 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG MDM2 NFE2L2 NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I UBR1 UBR2 UBR5 ZNF212	12 interacting genes: ATF3 BATF BATF2 BATF3 CEBPA CEBPG CLOCK DDIT3 EP300 EPAS1 HLF TEF
Entrez ID		467	1628
HPRD ID		04395	00497
Ensembl ID		ENSG00000162772	ENSG00000105516
Uniprot IDs		P18847	Q10586
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of RNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Promoter-specific Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Developmental Process DNA Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Developmental Process Intracellular Signaling Cassette Cellular Response To Stress Intracellular Signal Transduction	Chromatin DNA-binding Transcription Factor Activity RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Mononuclear Cell Differentiation Leukocyte Differentiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Myeloid Dendritic Cell Differentiation Positive Regulation Of Biosynthetic Process Transcription Regulator Complex CHOP-ATF3 Complex Intracellular Signaling Cassette Myeloid Dendritic Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process CHOP-C/EBP Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Dendritic Cell Differentiation Myeloid Leukocyte Differentiation Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Developmental Process Cellular Developmental Process
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