ATF3 and UBR2

Number of citations of the paper that reports this interaction (PubMedID 32692156)
126

Data Source:
BioGRID (protein complementation assay)

		ATF3	UBR2
Description		activating transcription factor 3	ubiquitin protein ligase E3 component n-recognin 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Golgi Apparatus Centrosome Nuclear Body Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex CHOP-ATF3 Complex	Ubiquitin Ligase Complex Chromatin Nucleus Chromosome Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity L-leucine Binding Histone H2A Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Transposable Element Silencing Protein Ubiquitination Protein Catabolic Process Heterochromatin Formation Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To L-leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Regulation of PD-L1(CD274) transcription	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Pseudoephedrine
Diseases
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Cerebral amyloid deposition (PET imaging) ( 26252872) Coronary artery disease ( 29212778) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122)	HDL cholesterol levels in HIV infection ( 33109212) Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein levels ( 29403010)
Interacting Genes		50 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG MDM2 NFE2L2 NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I UBR1 UBR2 UBR5 ZNF212	11 interacting genes: ATF3 CRYAA H2AC20 H2BC8 NTAN1 NTAQ1 PKN1 SUOX UBE2B UBE2D2 UBE2H
Entrez ID		467	23304
HPRD ID		04395	09853
Ensembl ID		ENSG00000162772	ENSG00000024048
Uniprot IDs		P18847	B3KXG6 Q8IWV8
PDB IDs			3NY2 3NY3 5TDA 5TDB 5TDD 5UM3
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of RNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Promoter-specific Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Developmental Process DNA Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Developmental Process Intracellular Signaling Cassette Cellular Response To Stress Intracellular Signal Transduction	Protein-N-terminal Asparagine Amidohydrolase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Nucleus Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Sulfite Oxidase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Protein Autoubiquitination CHOP-ATF3 Complex Protein Heterodimerization Activity Post-translational Protein Modification Chromatin Organization Positive Regulation Of Reciprocal Meiotic Recombination Structural Constituent Of Chromatin Histone H3T11 Kinase Activity Molybdenum Ion Binding Protein Modification Process Nucleosome Molybdopterin Cofactor Binding Macromolecule Catabolic Process HULC Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?