ATF3 and SH2D1A

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		ATF3	SH2D1A
Description		activating transcription factor 3	SH2 domain containing 1A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Golgi Apparatus Centrosome Nuclear Body Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex CHOP-ATF3 Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Regulation of PD-L1(CD274) transcription	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Pseudoephedrine
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Cerebral amyloid deposition (PET imaging) ( 26252872) Coronary artery disease ( 29212778) Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) ( 29923122)
Interacting Genes		50 interacting genes: APPL2 ATF2 ATF4 BATF BATF3 CEBPE CEBPG CREB3 CREBBP CRK DBP DDIT3 DNMT3L DOK5 FGFR3 FOS FOSL1 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 ID3 IGSF21 JUN JUND KAT5 LRIF1 MAFF MAFG MDM2 NFE2L2 NFKB1 NUF2 PDX1 POLR3D SH2D1A SMAD3 SRA1 SS18L1 STAT1 STAT3 SUV39H1 TP53 TP73 UBE2I UBR1 UBR2 UBR5 ZNF212	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		467	4068
HPRD ID		04395	02390
Ensembl ID		ENSG00000162772	ENSG00000183918
Uniprot IDs		P18847	O60880
PDB IDs			1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Integrated Stress Response Signaling Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding Negative Regulation Of RNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Promoter-specific Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Stress Regulation Of Developmental Process DNA Binding DNA-binding Transcription Factor Binding Transcription Regulator Complex Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Developmental Process Intracellular Signaling Cassette Cellular Response To Stress Intracellular Signal Transduction	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response
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