MLPH and RAB27B

Number of citations of the paper that reports this interaction (PubMedID 11856727)
0

Data Source:
HPRD (in vivo)

		MLPH	RAB27B
Description		melanophilin	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Myosin Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Melanosome Transport	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Regulation of MITF-M-dependent genes involved in pigmentation	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Central corneal thickness ( 32528159) Heel bone mineral density ( 28869591 30598549) Height ( 33713608) Intraocular pressure ( 29617998) Prostate cancer ( 21743057)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		7 interacting genes: BLOC1S6 C1orf216 MTDH MYO5A RAB27A RAB27B RECK	10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		79083	5874
HPRD ID		09409	04846
Ensembl ID		ENSG00000115648	ENSG00000041353
Uniprot IDs		Q9BV36	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?		Pigment Granule Localization Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Melanosome Establishment Of Vesicle Localization Vesicle Localization Myosin V Binding Late Endosome Melanocyte Differentiation Pigment Cell Differentiation Exocytic Vesicle Cytoskeleton-dependent Intracellular Transport Multivesicular Body Membrane Synaptic Vesicle Transport Establishment Of Organelle Localization Anterograde Axonal Transport Pigmentation Multivesicular Body Sorting Pathway Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Apical Plasma Membrane Secretion By Cell GDP Binding Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Protein Transport Axo-dendritic Transport Positive Regulation Of Exocytosis Organelle Localization Blood Coagulation Secretory Granule Ruffle Coagulation Secretion Hemostasis Establishment Of Protein Localization Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Complement-dependent Cytotoxicity Regulation Of Establishment Of Blood-brain Barrier Intracellular Nitric Oxide Homeostasis Exosomal Secretion Establishment Of Localization In Cell	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel
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