MLPH and RAB27A

Number of citations of the paper that reports this interaction (PMID 11980908)
70

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MLPH	RAB27A
Gene Name		melanophilin	RAB27A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Microtubule Organizing Center Dendrite Cortical Actin Cytoskeleton Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Actin Binding Rab GTPase Binding Myosin V Binding Metal Ion Binding Microtubule Plus-end Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Protein Targeting Melanocyte Differentiation Melanosome Localization	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS		Prostate cancer ( 21743057)
Protein-Protein Interactions		3 interactors: MYO5A RAB27A RAB27B	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		79083	5873
HPRD ID		09409	04845
Ensembl ID		ENSG00000115648	ENSG00000069974
Uniprot IDs		B3KSS2 G5E9G5 Q9BV36	A2RU94 P51159
PDB IDs
Enriched GO Terms of Interacting Partners?		Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Cellular Pigmentation Multivesicular Body Sorting Pathway Pigmentation Protein Secretion Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Exocytosis Organelle Localization Melanocyte Differentiation Neuroepithelial Cell Differentiation Secretion By Cell Rab Protein Signal Transduction Developmental Pigmentation Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Secretion Vesicle Docking Membrane Docking Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Regulation Of Exocytosis Cellular Protein Localization Protein Transport Vesicle-mediated Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Establishment Of Protein Localization Ras Protein Signal Transduction Intracellular Transport Endoplasmic Reticulum Localization Vesicle Transport Along Actin Filament Exosomal Secretion Protein Localization Positive Regulation Of Secretion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Localization In Cell Natural Killer Cell Degranulation Regulation Of Vesicle-mediated Transport Locomotion Involved In Locomotory Behavior Endomembrane System Organization Secretory Granule Localization T Cell Mediated Cytotoxicity Cellular Localization Epithelial Cell Differentiation Synaptic Transmission	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?		blue breeds californian castor checkered coat colour colours cosegregation dilute diluted eumelanic fairy frameshift grey griscelli indel lod marburg melanophilin pearly pheomelanic pigmentation pigmentations rab27a rex segregating sib vienna	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?		blue breeds californian castor checkered coat colour colours cosegregation dilute diluted eumelanic fairy frameshift grey griscelli indel lod marburg melanophilin pearly pheomelanic pigmentation pigmentations rex segregating sib vienna	adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?		rab27a