MYCN and HUWE1

Number of citations of the paper that reports this interaction (PubMedID 18488021)
48

Data Source:
BioGRID (enzymatic study)

		MYCN	HUWE1
Description		MYCN proto-oncogene, bHLH transcription factor	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Histone Ubiquitin Ligase Activity
	Biological Process	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lung Development Embryonic Digit Morphogenesis Positive Regulation Of Programmed Cell Death Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Autosome Genomic Imprinting Positive Regulation Of MiRNA Transcription Negative Regulation Of Reactive Oxygen Species Metabolic Process	Protein Polyubiquitination DNA Repair Base-excision Repair Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Golgi Organization Canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Fusion Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Membrane Fusion Protein K48-linked Ubiquitination Protein Branched Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Type 2 Mitophagy
Pathways		Signaling by ALK Regulation of CDH1 mRNA translation by microRNAs TGFBR3 expression Regulation of PD-L1(CD274) transcription	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Neuroblastoma Feingold syndrome	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Lymphocyte count ( 32888494) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)	Bipolar disorder ( 31043756) Body mass index ( 28892062) Educational attainment (years of education) ( 30038396)
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L FBXW7 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 UBE3A UBR4 YAF2 YBX1 YEATS4 ZBTB17	41 interacting genes: ABL1 ATOH1 CALM1 CASP1 CCL1 CD274 CDKN2A CLIC6 CREBBP CUL4B DDIT4 ERG H2AX H2BC3 LAPTM5 MCL1 MYCN NRIP1 PCNT PIAS2 POLB POLL PPP5C PTOV1 RNF10 RNF11 SMAD2 SMAD9 SUMO2 TBP TNS2 TP53 UBA6 UBC UBE2D1 UBE2D2 UBE2G1 UBE2L3 UBE2Z WBP2 WIPI2
Entrez ID		4613	10075
HPRD ID		01278	06608
Ensembl ID		ENSG00000134323	ENSG00000086758
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	Q7Z6Z7
PDB IDs		5G1X 7ZTL	2EKK 2MUL 3G1N 3H1D 5C6H 5LP8 6FYH 6MIW 6PFL 7AZX 7JQ9 7MOP 7MWD 7MWE 7MWF 8R7O 8RD0 8RD1 8RD7
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macroautophagy Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Positive Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Polyubiquitination Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction DNA Repair Mad-Max Complex DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process	Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Modification By Small Protein Conjugation Protein-containing Complex Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Modification-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stress DNA Damage Response Protein Metabolic Process Negative Regulation Of Gliogenesis Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Enzyme Binding Protein Polyubiquitination Regulation Of Transcription By RNA Polymerase II Chromatin Ubiquitin-dependent Protein Catabolic Process Cytosol RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway DNA Binding SUMO Transferase Activity Double-strand Break Repair Damaged DNA Binding Signal Transduction Catabolic Process DNA Repair SMAD Protein Signal Transduction Disordered Domain Specific Binding Regulation Of RNA Metabolic Process
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