MYCN and SP1

Number of citations: 0 (PubMedID 21123453)
Data Source: BioGRID (affinity chromatography technology, pull down)

		MYCN	SP1
Name		MYCN proto-oncogene, bHLH transcription factor	Sp1 transcription factor
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lung Development Embryonic Digit Morphogenesis Positive Regulation Of Programmed Cell Death Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Autosome Genomic Imprinting Positive Regulation Of MiRNA Transcription Negative Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Cellular Response To Zinc Ion Starvation Positive Regulation Of Blood Vessel Endothelial Cell Migration Host-mediated Activation Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estrogen Stimulus Positive Regulation Of Amyloid-beta Formation Cellular Response To Wortmannin Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by ALK Regulation of CDH1 mRNA translation by microRNAs TGFBR3 expression Regulation of PD-L1(CD274) transcription	PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression SARS-CoV-1 targets host intracellular signalling and regulatory pathways Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription Positive Regulation of CDH1 Gene Transcription NFE2L2 regulating tumorigenic genes TGFBR3 expression
Diseases		Neuroblastoma Feingold syndrome	None
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907 ) Basal cell carcinoma ( 25855136 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 31562340 ) Lymphocyte count ( 32888494 ) Metabolite levels ( 23823483 ) Nonsyndromic cleft lip ( 31609978 ) Nonsyndromic cleft palate ( 31609978 ) Pulmonary function (smoking interaction) ( 23284291 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Wilms tumor ( 22544364 )	Apolipoprotein B levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) Hypospadias (moderate to severe) ( 31856834 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 27863252 ) Parkinsonism in frontotemporal lobe dementia ( 29724592 ) Percentage gas trapping ( 26030696 ) Progressive supranuclear palsy ( 30089514 ) Red blood cell count ( 27863252 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L FBXW7 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 UBE3A UBR4 YAF2 YBX1 YEATS4 ZBTB17	149 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KAT2B KIF1A KLF10 KLF4 KLF6 LDB1 LINC00955 LMO2 MAP1LC3A MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RMP64 RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB5 ZBTB7A
Entrez ID		4613	6667
HPRD ID		01278	01796
Ensembl ID		ENSG00000134323	ENSG00000185591
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	P08047
PDB IDs		5G1X 7ZTL	1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP
GO Terms Enriched among Interactors		Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macroautophagy Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Positive Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Polyubiquitination Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction DNA Repair Mad-Max Complex DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleoplasm Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Sequence-specific Double-stranded DNA Binding Regulation Of MiRNA Metabolic Process DNA-templated Transcription Regulation Of MiRNA Transcription Regulation Of Developmental Process Chromatin Binding Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding