MYCN and UBR4

Number of citations of the paper that reports this interaction (PubMedID 9653139)
29

Data Source:
BioGRID (enzymatic study)

		MYCN	UBR4
Description		MYCN proto-oncogene, bHLH transcription factor	ubiquitin protein ligase E3 component n-recognin 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lung Development Embryonic Digit Morphogenesis Positive Regulation Of Programmed Cell Death Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Autosome Genomic Imprinting Positive Regulation Of MiRNA Transcription Negative Regulation Of Reactive Oxygen Species Metabolic Process	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Fatty Acid Biosynthetic Process Response To Oxidative Stress Endosome Organization Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process Protein Stabilization Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling Protein Branched Polyubiquitination
Pathways		Signaling by ALK Regulation of CDH1 mRNA translation by microRNAs TGFBR3 expression Regulation of PD-L1(CD274) transcription	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Verpasep caltespen Picolinic acid
Diseases		Neuroblastoma Feingold syndrome
GWAS		Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Lymphocyte count ( 32888494) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)
Interacting Genes		20 interacting genes: CSNK2A1 CSNK2A2 DOT1L FBXW7 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 UBE3A UBR4 YAF2 YBX1 YEATS4 ZBTB17	18 interacting genes: ACE2 ADRA1A AGTR1 CALM1 ERG HSPA13 MTNR1A MTNR1B MYCN PRPF40A SRGN SRPK2 SUMO2 TTC3 UBC UBE2B UBE2D2 UBE2L3
Entrez ID		4613	23352
HPRD ID		01278	10184
Ensembl ID		ENSG00000134323	ENSG00000127481
Uniprot IDs		A0A1W2PPD9 P04198 Q9H224	Q5T4S7
PDB IDs		5G1X 7ZTL	8B5W 8BTL 8J9Q 8J9R
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macroautophagy Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Positive Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Polyubiquitination Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction DNA Repair Mad-Max Complex DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process	Regulation Of Vasoconstriction Regulation Of Blood Circulation Melatonin Receptor Activity Ubiquitin Conjugating Enzyme Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Action Potential Positive Regulation Of Cardiac Muscle Contraction Protein Modification By Small Protein Conjugation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Nucleoplasm Positive Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction Protein Modification Process Proteolysis Protein Tag Activity Ubiquitin-protein Transferase Activity Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of System Process Protein Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Circulatory System Process Protein Ubiquitination Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Reactive Oxygen Species Metabolic Process Presynaptic Cytosol G Protein-coupled Receptor Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Muscle Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Protein K11-linked Ubiquitination G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Angiotensin Type I Receptor Activity Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Regulation Of Heart Contraction Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
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