MYB and KAT2A

Number of citations of the paper that reports this interaction (PubMedID 10656693)
0

Data Source:
BioGRID (enzymatic study)

		MYB	KAT2A
Description		MYB proto-oncogene, transcription factor	lysine acetyltransferase 2A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix RNA Polymerase II Transcription Regulator Complex	Histone Acetyltransferase Complex SAGA Complex Chromatin Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle ATAC Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding WD40-repeat Domain Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Histone H3 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein Phosphatase Binding Histone Deacetylase Binding Histone H3K9 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone Glutaryltransferase Activity DNA-binding Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia In Utero Embryonic Development Response To Ischemia Regulation Of DNA-templated Transcription Calcium Ion Transport Regulation Of Gene Expression Skeletal Muscle Cell Proliferation Stem Cell Division Myeloid Cell Differentiation B Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process T-helper 2 Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Homeostasis Of Number Of Cells Positive Regulation Of Glial Cell Proliferation Myeloid Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Interleukin-6 Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Hepatic Stellate Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Gluconeogenesis Regulation Of DNA Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Heart Development Long-term Memory Regulation Of Gene Expression Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Multicellular Organism Growth Protein Modification Process Regulation Of RNA Splicing Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Negative Regulation Of Centriole Replication Fibroblast Proliferation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Regulation Of Cell Division Regulation Of Cell Cycle Limb Development Regulation Of Cartilage Development Regulation Of Small Molecule Metabolic Process Cellular Response To Tumor Necrosis Factor Peptidyl-lysine Glutarylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production Specification of the neural plate border	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis Formation of WDR5-containing histone-modifying complexes Formation of paraxial mesoderm
Drugs			Coenzyme A
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301 33339817 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil count ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 28898252) HbA2 levels ( 23043469) Hematocrit ( 19862010 29403010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 19862010 29403010 28548082 28453575 28031487 19853236 20139978 23263863) Mean corpuscular hemoglobin concentration ( 29403010 23263863 20139978) Mean corpuscular volume ( 19853236 29403010 19862010 23263863 20139978 28031487 28453575) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 29066854 24026423 33545615 26805783 28031487 22423221 19853236 22139419 20139978 29403010) Red blood cell count ( 29403010 28453575 28031487 20139978) Red blood cell traits ( 23935956 20927387) White blood cell count ( 29403010 20139978 32888494) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Coronary artery disease ( 29212778 33020668) Inflammatory bowel disease ( 26278503) Mean reticulocyte volume ( 32888494) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	67 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPA CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL ECHS1 EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2AC4 H2BC21 H2BC3 H3-4 H3C1 H3C14 H4C14 H4C16 H4C7 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PRKDC PYGO2 RASSF1 RBPJ RELA RPA1 SIRT2 SNCA STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		4602	2648
HPRD ID		01810	03807
Ensembl ID		ENSG00000118513	ENSG00000108773
Uniprot IDs		P10242 Q708E9	Q92830
PDB IDs			1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P 8E6O 8H65 8H66 8H6C 8H6D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Nucleus PML Body Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA Binding Chromatin Organization Regulation Of Primary Metabolic Process Rhythmic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process SUMO Transferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Protein Sumoylation Histone H3K18 Acetyltransferase Activity Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Protein Stability Chromatin Ubiquitin Protein Ligase Binding DNA Damage Response Protein Modification Process Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Nucleus Nucleoplasm Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Nucleosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Chromatin Binding Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Protein Heterodimerization Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Hemopoiesis DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Mitotic Cell Cycle Phase Transition Mononuclear Cell Differentiation Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Cell Cycle Phase Transition Chromosome
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