MYB and RQCD1

Number of citations of the paper that reports this interaction (PMID 15209511)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MYB	RQCD1
Gene Name		v-myb avian myeloblastosis viral oncogene homolog	RCD1 required for cell differentiation1 homolog (S. pombe)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Nuclear Matrix	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane CCR4-NOT Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding WD40-repeat Domain Binding	Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Calcium Ion Transport Blood Coagulation B Cell Differentiation Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Embryonic Digestive Tract Development Homeostasis Of Number Of Cells Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Interleukin-6	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Sex Differentiation Gene Expression Cytokine-mediated Signaling Pathway Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Pathways		Factors involved in megakaryocyte development and platelet production	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) HbA2 levels ( 23043469) Hematocrit ( 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863 19853236) Mean corpuscular hemoglobin ( 23263863 20139978 19862010) Mean corpuscular hemoglobin concentration ( 23263863 20139978) Mean corpuscular volume ( 23263863 20139978 19862010) Mean platelet volume ( 22423221) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet counts ( 22139419 20139978) Red blood cell count ( 20139978) Red blood cell traits ( 20927387) White blood cell count ( 20139978) White blood cell types ( 21738478)
Protein-Protein Interactions		43 interactors: BTRC CCND3 CEBPB CEBPE CHD3 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAX5 PIAS1 PML PPM1K RBX1 RPL4 RQCD1 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	6 interactors: AKT1 EGFR GIGYF1 GIGYF2 GRB10 MYB
Entrez ID		4602	9125
HPRD ID		01810	08828
Ensembl ID		ENSG00000118513	ENSG00000144580
Uniprot IDs		P10242 Q14025 Q708E1 Q708E9	B5MDQ4 B7Z1E5 D5MQE1 Q92600
PDB IDs			2FV2
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Protein Sumoylation Cellular Protein Modification Process Rhythmic Process Protein Modification By Small Protein Conjugation Developmental Process Peptidyl-lysine Modification PML Body Organization Cell Cycle Regulation Of Signal Transduction Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process	Insulin-like Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To UV-A Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Mitotic Cell Cycle Response To Epidermal Growth Factor Homeostasis Of Number Of Cells Positive Regulation Of Vasoconstriction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Glycogen Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Glycogen Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cell Cycle Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Glucose Import Cellular Response To Mechanical Stimulus Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Organonitrogen Compound Homeostatic Process Regulation Of Oxidoreductase Activity Embryonic Organ Development Gland Development In Utero Embryonic Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Alkanesulfonate Metabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Glucose Transport Glial Cell Development Cellular Response To Hormone Stimulus Regulation Of Glucose Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Reactive Oxygen Species Metabolic Process Embryonic Placenta Development Cell Activation Response To UV Cellular Response To Stimulus Digestive Tract Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Tagcloud ?		amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates
Tagcloud (Difference) ?		amphibian amphibians assume definitive deoxynucleotidyl ectotherms elasmobranchs elegant extraembryonic gata gnathostomes grafting hematopoiesis icm ikaros intraembryonic lck leydig lymphopoiesis mesoderm myeloblastosis oellacher primitive rag spiral tdt teleosts thymopoietic undeniably vertebrates
Tagcloud (Intersection) ?