MYB and SKI

Number of citations of the paper that reports this interaction (PubMedID 14761981)
0

Data Source:
BioGRID (pull down)

		MYB	SKI
Description		MYB proto-oncogene, transcription factor	SKI proto-oncogene
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Nuclear Body PML Body Transcription Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding WD40-repeat Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding SMAD Binding Histone Deacetylase Inhibitor Activity DNA-binding Transcription Factor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia In Utero Embryonic Development Response To Ischemia Regulation Of DNA-templated Transcription Calcium Ion Transport Regulation Of Gene Expression Skeletal Muscle Cell Proliferation Stem Cell Division Myeloid Cell Differentiation B Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process T-helper 2 Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Homeostasis Of Number Of Cells Positive Regulation Of Glial Cell Proliferation Myeloid Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Interleukin-6 Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Hepatic Stellate Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Lens Morphogenesis In Camera-type Eye Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification Negative Regulation Of Schwann Cell Proliferation Myotube Differentiation Olfactory Bulb Development Myelination In Peripheral Nervous System Positive Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Camera-type Eye Development Positive Regulation Of DNA Binding Nose Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Skeletal Muscle Fiber Development Cell Motility Regulation Of Neurogenesis Roof Of Mouth Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Face Morphogenesis Bone Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Muscle Structure Development
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production Specification of the neural plate border	Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301 33339817 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil count ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 28898252) HbA2 levels ( 23043469) Hematocrit ( 19862010 29403010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 19862010 29403010 28548082 28453575 28031487 19853236 20139978 23263863) Mean corpuscular hemoglobin concentration ( 29403010 23263863 20139978) Mean corpuscular volume ( 19853236 29403010 19862010 23263863 20139978 28031487 28453575) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 29066854 24026423 33545615 26805783 28031487 22423221 19853236 22139419 20139978 29403010) Red blood cell count ( 29403010 28453575 28031487 20139978) Red blood cell traits ( 23935956 20927387) White blood cell count ( 29403010 20139978 32888494) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Coronary artery disease ( 29212778) Liver enzyme levels (alanine transaminase) ( 33972514) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) PR interval ( 30046033 32439900) Systolic blood pressure ( 30224653) Urate levels ( 31578528)
Interacting Genes		49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	20 interacting genes: AKT1 GLI2 GLI3 HIPK2 JUN MECP2 MYB NCOR1 NFIX PML SIN3A SKIL SMAD1 SMAD2 SMAD3 SMAD4 SNW1 SPI1 TGFBR1 TRIM28
Entrez ID		4602	6497
HPRD ID		01810	01271
Ensembl ID		ENSG00000118513	ENSG00000157933
Uniprot IDs		P10242 Q708E9	P12755
PDB IDs			1MR1 1SBX 5XOD 6ZVQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Nucleus PML Body Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA Binding Chromatin Organization Regulation Of Primary Metabolic Process Rhythmic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process SUMO Transferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Protein Sumoylation Histone H3K18 Acetyltransferase Activity Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Protein Stability Chromatin Ubiquitin Protein Ligase Binding DNA Damage Response Protein Modification Process Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of DNA-templated Transcription Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MiRNA Transcription Chromatin Binding Cellular Developmental Process SMAD Protein Complex Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Cell Population Proliferation
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