ANXA7 and COL11A2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		ANXA7	COL11A2
Name		annexin A7	collagen type XI alpha 2 chain
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Chromaffin Granule Membrane Extracellular Exosome	Extracellular Region Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Phosphatidylserine Binding RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Autophagy Negative Regulation Of Gene Expression Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion Response To Phorbol 13-acetate 12-myristate	Skeletal System Development Sensory Perception Of Sound Collagen Fibril Organization Cartilage Development Roof Of Mouth Development Soft Palate Development
Pathways		None	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Diseases		None	Deafness, autosomal recessive Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Deafness, autosomal dominant Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Copper levels ( 26025379 )	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956 ) Asthma ( 30929738 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Height ( 31217584 ) Hip circumference adjusted for BMI ( 34021172 ) Lung cancer ( 28604730 ) Rosacea symptom severity ( 29771307 ) Sjögren's syndrome ( 24097066 ) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781 ) Wegener's granulomatosis ( 23740775 )
Interacting Genes		109 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CREBBP CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 HUNK INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OGT OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431	3 interacting genes: ANXA7 PIN1 TK1
Entrez ID		310	1302
HPRD ID		01720	00376
Ensembl ID		ENSG00000138279	ENSG00000204248
Uniprot IDs		B2R657 P20073	A0A0C4DFS1 A0A0G2JL35 A0A0G2JL78 A0A140TA43 P13942 Q4VXY6
PDB IDs		8W5S	Not available
GO Terms Enriched among Interactors		TORC1 Signaling Extracellular Exosome TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Metabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Cytoplasm Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Extracellular Matrix Positive Regulation Of Biosynthetic Process Positive Regulation Of TOR Signaling Developmental Process Regulation Of Metabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Protein Deubiquitination Cellular Response To Nutrient Levels Regulation Of Proteolysis Histone H3T6 Kinase Activity Structural Constituent Of Cytoskeleton Positive Regulation Of Protein Metabolic Process Platelet Alpha Granule Lumen Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Blood Microparticle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Cytoplasmic Translation Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Matrix Response To Interleukin-1 Response To Cytokine Regulation Of Protein Localization Negative Regulation Of Signal Transduction Calyx Of Held Negative Regulation Of Translational Initiation Protein Kinase C Signaling Proteasomal Protein Catabolic Process	Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Cis-trans Isomerase Activity DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sodium Arsenite Protein-containing Complex Assembly Phosphoserine Residue Binding Thymidine Metabolic Process Thymidine Biosynthetic Process Chromaffin Granule Membrane Response To Metal Ion Protein-containing Complex Organization Deoxyribonucleoside Monophosphate Biosynthetic Process Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Response To Phorbol 13-acetate 12-myristate Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Cellular Response To Arsenic-containing Substance Cellular Response To Unfolded Protein Cellular Response To Cadmium Ion Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Androgen Receptor Signaling Pathway Microtubule Polymerization Cellular Response To Copper Ion Nuclear Androgen Receptor Binding Cellular Response To Topologically Incorrect Protein Response To Salt Response To Arsenic-containing Substance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Protein Targeting To Mitochondrion Postsynaptic Cytosol Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Amyloid-beta Formation