ANXA7 and FAF1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ANXA7	FAF1
Description		annexin A7	Fas associated factor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Vesicle Membrane Membrane Extracellular Matrix Chromaffin Granule Membrane Extracellular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Endomembrane System CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm Ooplasm
	Molecular Function	Phosphatidylserine Binding RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Autophagy Negative Regulation Of Gene Expression Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion Response To Phorbol 13-acetate 12-myristate	Apoptotic Process Regulation Of Cell Adhesion Fas Signaling Pathway ERAD Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Drugs
Diseases
GWAS		Copper levels ( 26025379)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Body mass index and type 2 diabetes (pairwise) ( 33619380) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Left ventricle wall thickness ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 33830993 31194737) Neutrophil percentage of white cells ( 32888494) Pancreas fat ( 34128465) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 30578418 27841878) QRS duration ( 21076409 30679814) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 24509480 26818947 28869590 30718926 32499647) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		109 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CREBBP CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 HUNK INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OGT OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431	49 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CBS CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NEDD8 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD WWP2 XIAP YTHDF3
Entrez ID		310	11124
HPRD ID		01720	05124
Ensembl ID		ENSG00000138279	ENSG00000185104
Uniprot IDs		B2R657 P20073	Q9UNN5
PDB IDs		8W5S	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M 7FGM 7FGN 8KG2
Enriched GO Terms of Interacting Partners?		TORC1 Signaling Extracellular Exosome TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Metabolic Process Positive Regulation Of TORC1 Signaling Positive Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Cytoplasm Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal Extracellular Matrix Positive Regulation Of Biosynthetic Process Positive Regulation Of TOR Signaling Developmental Process Regulation Of Metabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Perinuclear Region Of Cytoplasm Regulation Of Protein Metabolic Process Protein Deubiquitination Cellular Response To Nutrient Levels Regulation Of Proteolysis Histone H3T6 Kinase Activity Structural Constituent Of Cytoskeleton Positive Regulation Of Protein Metabolic Process Platelet Alpha Granule Lumen Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Blood Microparticle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Cytoplasmic Translation Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Nuclear Matrix Response To Interleukin-1 Response To Cytokine Regulation Of Protein Localization Negative Regulation Of Signal Transduction Calyx Of Held Negative Regulation Of Translational Initiation Protein Kinase C Signaling Proteasomal Protein Catabolic Process	Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Lipid Cytoplasm Positive Regulation Of Protein Metabolic Process Regulation Of Interleukin-1 Production Regulation Of Innate Immune Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Immune System Process Negative Regulation Of Signal Transduction Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Interleukin-1 Beta Production Negative Regulation Of Signaling Negative Regulation Of Cell Communication CD95 Death-inducing Signaling Complex Positive Regulation Of Defense Response Catabolic Process
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