RPP14 and POP4

Number of citations of the paper that reports this interaction (PubMedID 15096576)
37

Data Source:
HPRD (in vitro)

		RPP14	POP4
Description		ribonuclease P/MRP subunit p14	POP4 ribonuclease P/MRP subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex Endoribonuclease Complex Ribonucleoprotein Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal TRNA Processing	TRNA 5'-leader Removal RRNA Processing RNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus
Drugs
Diseases
GWAS		Height ( 28552196) Hemoglobin levels ( 32327693) Mitochondrial heteroplasmy measurement ( 33731350) Platelet distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)	Body mass index ( 26426971) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Metabolite levels ( 23823483)
Interacting Genes		22 interacting genes: A2M ACTN2 ATP5F1B CAPZB DOCK7 EXOSC8 GEMIN2 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ ZNF277	7 interacting genes: AKT1 POP1 POP5 RPP14 RPP25 RPP30 RPP38
Entrez ID		11102	10775
HPRD ID		18001	09358
Ensembl ID		ENSG00000163684	ENSG00000105171
Uniprot IDs		O95059	O95707
PDB IDs		6AHR 6AHU	6AHR 6AHU
Enriched GO Terms of Interacting Partners?		Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex TRNA Metabolic Process RRNA Processing Ribonuclease P Complex TRNA Processing RRNA Metabolic Process RNA Processing Nucleolus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Nucleoplasm RNA Binding Nucleic Acid Metabolic Process Nucleus Actin Filament Uncapping Ribonuclease MRP Activity	Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Ribonuclease MRP Complex TRNA Processing TRNA Metabolic Process Nucleolar Ribonuclease P Complex RNA Processing RNA Metabolic Process Nucleolus Nucleic Acid Metabolic Process RRNA Processing Ribonuclease P Complex RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Binding Nucleoplasm Macromolecule Metabolic Process Regulation Of TRNA Methylation Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Endoribonuclease Complex Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Response To Rapamycin Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of TORC2 Signaling TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development
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