MZT1 and REPS1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		MZT1	REPS1
Description		mitotic spindle organizing protein 1	RALBP1 associated Eps domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Ring Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Interphase Microtubule Organizing Center	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Gamma-tubulin Complex Localization Microtubule Nucleation By Interphase Microtubule Organizing Center Mitotic Spindle Assembly	Endocytosis Endosomal Transport
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Chronotype ( 30696823) Obsessive-compulsive disorder ( 22889921)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Type 2 diabetes ( 32499647)
Interacting Genes		4 interacting genes: CINP CYGB REPS1 TRIM72	19 interacting genes: AKT1 ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2
Entrez ID		440145	85021
HPRD ID		19041	09687
Ensembl ID		ENSG00000204899	ENSG00000135597
Uniprot IDs		Q08AG7	B2R7D3 Q96D71
PDB IDs		6L81 6M33 6X0U 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 8RX1 8VRD 8VRJ 8VRK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Superoxide Dismutase Activity Catalase Activity Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Carbon Monoxide Binding Nitrite Reductase Activity Preribosome Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Oxygen Carrier Activity Removal Of Superoxide Radicals Negative Regulation Of Fibroblast Migration Mitogen-activated Protein Kinase Kinase Kinase Binding Oxygen Transport Negative Regulation Of Myotube Differentiation	Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Intracellular Signaling Cassette Import Into Cell Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Cytosol Protein-macromolecule Adaptor Activity Small GTPase-mediated Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Signal Transduction Organelle Organization Cellular Response To Decreased Oxygen Levels Response To Decreased Oxygen Levels Regulation Of Organelle Organization Cellular Response To Oxygen Levels Response To Oxygen Levels Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling PERK-mediated Unfolded Protein Response Receptor Internalization Establishment Of Protein Localization To Mitochondrion General Transcription Initiation Factor Binding TRAPPII Protein Complex TRAPPIII Protein Complex ERBB Signaling Pathway Ras Protein Signal Transduction Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Kinase Binding Cellular Localization Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction TRAPP Complex Cytoplasm Positive Regulation Of Growth Positive Regulation Of Organelle Assembly Kinase Binding Positive Regulation Of Cellular Component Biogenesis Intracellular Vesicle Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Response To Hypoxia
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