MZT1 and TRIM72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MZT1	TRIM72
Description		mitotic spindle organizing protein 1	tripartite motif containing 72
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GO Annotations	Cellular Component	Gamma-tubulin Ring Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Interphase Microtubule Organizing Center	Cytoplasm Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Sarcolemma
	Molecular Function	Protein Binding	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Gamma-tubulin Complex Localization Microtubule Nucleation By Interphase Microtubule Organizing Center Mitotic Spindle Assembly	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Organ Development Negative Regulation Of Myotube Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Chronotype ( 30696823) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		4 interacting genes: CINP CYGB REPS1 TRIM72	19 interacting genes: ABI2 C1orf216 GSK3B INSR IRS1 MED21 MZT1 NMI RAC1 RIPK1 SMARCD1 TCF12 TRIM32 UBE2D1 UBE2H UBE2I UBE2N VSIG4 ZNF655
Entrez ID		440145	493829
HPRD ID		19041	17412
Ensembl ID		ENSG00000204899	ENSG00000177238
Uniprot IDs		Q08AG7	Q6ZMU5
PDB IDs		6L81 6M33 6X0U 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 8RX1 8VRD 8VRJ 8VRK	3KB5 7XT2 7Y4S
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Superoxide Dismutase Activity Catalase Activity Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Carbon Monoxide Binding Nitrite Reductase Activity Preribosome Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Oxygen Carrier Activity Removal Of Superoxide Radicals Negative Regulation Of Fibroblast Migration Mitogen-activated Protein Kinase Kinase Kinase Binding Oxygen Transport Negative Regulation Of Myotube Differentiation	Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Polyubiquitination Regulation Of Macromolecule Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Polyubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Insulin Receptor Complex Positive Regulation Of Post-translational Protein Modification Regulation Of Glycogen Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Protein Modification Process Positive Regulation Of Signaling Regulation Of Neuron Differentiation Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Immune System Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Catabolic Process Insulin Receptor Signaling Pathway Signaling Adaptor Activity TOR Signaling Regulation Of Metabolic Process Regulation Of Cell Projection Assembly Negative Regulation Of TOR Signaling Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of RNA Biosynthetic Process Insulin-like Growth Factor Receptor Binding Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
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