SCN2A and RNF130

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SCN2A	RNF130
Description		sodium voltage-gated channel alpha subunit 2	ring finger protein 130
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex	Cytoplasm Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Transmembrane Transport Cellular Response To Hypoxia Cardiac Muscle Cell Action Potential Involved In Contraction	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 34002096 33263727 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)	LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)
Interacting Genes		5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B	14 interacting genes: ARPC4 EGFR FGFR3 PDCD1 SCN2A TGFBR1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z
Entrez ID		6326	55819
HPRD ID		03133	11504
Ensembl ID		ENSG00000136531	ENSG00000113269
Uniprot IDs		Q99250	E5RI87 Q2HIY3 Q86XS8
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?		Sodium Channel Regulator Activity Organelle Neuronal Action Potential Positive Regulation Of Sodium Ion Transport Intercalated Disc Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transport Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Arachidonate Secretion Positive Regulation Of Cell Communication By Electrical Coupling Action Potential Negative Regulation Of Icosanoid Secretion Oxidative Stress-induced Premature Senescence Transmembrane Transporter Binding Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Voltage-gated Potassium Channel Activity Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Monoatomic Ion Transport Adherens Junction Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Poly-N-acetyllactosamine Metabolic Process Glycosylation N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Macromolecule Glycosylation Carbohydrate Binding Regulation Of Arachidonate Secretion Stress-induced Premature Senescence Phospholipase A2 Inhibitor Activity Positive Regulation Of Arachidonate Secretion Negative Regulation Of Fatty Acid Transport Cellular Response To Sterol Depletion SREBP Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Ubiquitin-protein Transferase Activity Protein Polyubiquitination Nucleotide Binding Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein K63-linked Ubiquitination Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Protein Polyubiquitination Protein Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Catabolic Process Receptor Complex Regulation Of Protein Ubiquitination Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Multivesicular Body, Internal Vesicle Lumen Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Regulation Of Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Shc-EGFR Complex Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction
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