SCN2A and SCN4B

Number of citations: 32 (PubMedID 12930796)
Data Source: HPRD (in vitro, in vivo)

		SCN2A	SCN4B
Name		sodium voltage-gated channel alpha subunit 2	sodium voltage-gated channel beta subunit 4
Structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex	Voltage-gated Sodium Channel Complex Plasma Membrane Intercalated Disc Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding	Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Action Potential Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Transmembrane Transport Cellular Response To Hypoxia Cardiac Muscle Cell Action Potential Involved In Contraction	Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuronal Action Potential Sodium Ion Transmembrane Transport Establishment Of Localization In Cell Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil	Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Bipolar disorder ( 34002096 33263727 31043756 ) Diastolic blood pressure ( 30224653 ) Epilepsy ( 30531953 ) Factor VII activity ( 30642921 ) Febrile seizures ( 25344690 ) Febrile seizures (MMR vaccine-related) ( 25344690 ) Febrile seizures (MMR vaccine-unrelated) ( 25344690 ) Focal epilepsy ( 30531953 ) Generalized epilepsy ( 30531953 ) Periodontitis (DPAL) ( 24024966 ) Refractive error ( 32231278 ) Trunk fat mass ( 28552196 ) Urinary sodium excretion ( 31409800 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: B4GAT1 BAZ2B GALNT13 PKP4 PLA2R1	1 novel interactors: SC5D
Interacting Genes		5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B	2 interacting genes: SCN2A YIF1A
Entrez ID		6326	6330
HPRD ID		03133	09749
Ensembl ID		ENSG00000136531	ENSG00000177098
Uniprot IDs		Q99250	B0YJ93 Q8IWT1
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E	4MZ2 4MZ3 5XAW 6VSV 7DTD
GO Terms Enriched among Interactors		Sodium Channel Regulator Activity Organelle Neuronal Action Potential Positive Regulation Of Sodium Ion Transport Intercalated Disc Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transport Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Arachidonate Secretion Positive Regulation Of Cell Communication By Electrical Coupling Action Potential Negative Regulation Of Icosanoid Secretion Oxidative Stress-induced Premature Senescence Transmembrane Transporter Binding Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Voltage-gated Potassium Channel Activity Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Monoatomic Ion Transport Adherens Junction Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Poly-N-acetyllactosamine Metabolic Process Glycosylation N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Macromolecule Glycosylation Carbohydrate Binding Regulation Of Arachidonate Secretion Stress-induced Premature Senescence Phospholipase A2 Inhibitor Activity Positive Regulation Of Arachidonate Secretion Negative Regulation Of Fatty Acid Transport Cellular Response To Sterol Depletion SREBP Signaling Pathway	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Ferroptosis Negative Regulation Of Ferroptosis Voltage-gated Sodium Channel Complex Voltage-gated Sodium Channel Activity Node Of Ranvier Cholesterol Biosynthetic Process Sodium Channel Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Cation Channel Activity COPII-coated ER To Golgi Transport Vesicle Sterol Biosynthetic Process Cardiac Muscle Cell Action Potential