IDUA and MPP3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		IDUA	MPP3
Gene Name		iduronidase, alpha-L-	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Coated Vesicle Lysosomal Lumen Extracellular Vesicular Exosome	Integral Component Of Plasma Membrane
	Molecular Function	L-iduronidase Activity Receptor Binding	Guanylate Kinase Activity PDZ Domain Binding
	Biological Process	Cell Morphogenesis Carbohydrate Metabolic Process Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Lysosome Organization Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Catabolic Process Limb Morphogenesis Small Molecule Metabolic Process Skeletal System Morphogenesis Chemical Homeostasis	Signal Transduction Nucleotide Phosphorylation
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		1 interactors: MPP3	33 interactors: APP ARL2BP CADM1 CCDC137 CRABP1 ERBB2IP EZR FAM171B GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZPR1
Entrez ID		3425	4356
HPRD ID		02016	03069
Ensembl ID		ENSG00000127415	ENSG00000161647
Uniprot IDs		B3KWK6 P35475	Q13368
PDB IDs		1Y24 3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Binding Cell Growth Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Binding Regulation Of Protein Homodimerization Activity Growth Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle MRNA Metabolic Process Positive Regulation Of Binding Cellular Response To Epidermal Growth Factor Stimulus Multicellular Organismal Development Asymmetric Protein Localization System Development Establishment Or Maintenance Of Apical/basal Cell Polarity RNA Processing DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Signal Transduction Response To Epidermal Growth Factor DNA Strand Elongation Organelle Organization Exocytosis RNA Splicing Signaling Cellular Protein Localization G1/S Transition Of Mitotic Cell Cycle Cell Communication Nervous System Development Receptor Internalization Cellular Component Assembly Positive Regulation Of Interleukin-15 Production Nuclear Speck Organization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Neurotrophin Production Dermatan Sulfate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Pre-mRNA Catabolic Process DNA Endoreduplication Signal Transduction Positive Regulation Of Innate Immune Response Protein Localization Regulation Of Phosphorus Metabolic Process
Tagcloud ?		attain avoiding beauty c57bl correcting cumulatively cyclophosphamide decay deliver drive hydrodynamically hyperactive iduronidase immunocompetent immunosuppression infuse integrating minimize mucopolysaccharidosis plasmids sb sb100x shutdown sleeping transgene transposase transposition transposon vis	17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue
Tagcloud (Difference) ?		attain avoiding beauty c57bl correcting cumulatively cyclophosphamide decay deliver drive hydrodynamically hyperactive iduronidase immunocompetent immunosuppression infuse integrating minimize mucopolysaccharidosis plasmids sb sb100x shutdown sleeping transgene transposase transposition transposon vis	17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue
Tagcloud (Intersection) ?