IDUA

Gene Name		iduronidase, alpha-L-
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Gene Ontology Annotations	Cellular Component	Coated Vesicle Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	L-iduronidase Activity Receptor Binding
	Biological Process	Cell Morphogenesis Carbohydrate Metabolic Process Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Lysosome Organization Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Catabolic Process Limb Morphogenesis Small Molecule Metabolic Process Skeletal System Morphogenesis Chemical Homeostasis
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-protein Interactions		1 interactors: MPP3
Entrez ID		3425
HPRD ID		02016
Ensembl ID		ENSG00000127415
Uniprot IDs		B3KWK6 P35475
PDB IDs		1Y24 3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4
Enriched GO Terms of Interacting Partners?
Tagcloud ?		attain avoiding beauty c57bl correcting cumulatively cyclophosphamide decay deliver drive hydrodynamically hyperactive iduronidase immunocompetent immunosuppression infuse integrating minimize mucopolysaccharidosis plasmids sb sb100x shutdown sleeping transgene transposase transposition transposon vis