EPHB3 and NFRKB

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		EPHB3	NFRKB
Name		EPH receptor B3	nuclear factor related to kappaB binding protein
Structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite Cell Projection	Nucleus Nucleoplasm Ino80 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity	Protease Binding DNA Binding Protein Binding
	Biological Process	Angiogenesis Urogenital System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Axonal Fasciculation Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Embryonic Development Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	UCH proteinases DNA Damage Recognition in GG-NER
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680 ) Nicotine dependence symptom count ( 25555482 ) Nose size ( 27182965 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	High light scatter reticulocyte count ( 32888494 ) Night sleep phenotypes ( 27126917 ) Reticulocyte count ( 32888494 )
Interacting Genes		14 interacting genes: AFDN CRK EFNB3 ERBB2 FBXO7 FYN GBE1 HPCAL1 HSF2BP LNX1 NFRKB RASA1 RNF186 RYK	3 interacting genes: EPHB3 NFKB1 TRDMT1
Entrez ID		2049	4798
HPRD ID		03502	01240
Ensembl ID		ENSG00000182580	ENSG00000170322
Uniprot IDs		P54753	Q6P4R8
PDB IDs		3P1I 3ZFY 5L6O 5L6P	3U21 4UF5 4UF6 4WLP
GO Terms Enriched among Interactors		Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Neuron Projection Guidance Axon Guidance Positive Regulation Of Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Reelin-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Protein Tyrosine Kinase Activity Regulation Of Cell Shape Positive Regulation Of Protein Targeting To Membrane Regulation Of Developmental Process Signaling Receptor Binding Regulation Of Protein Targeting To Membrane Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Projection Organization Phosphotyrosine Residue Binding Negative Regulation Of Immune System Process Cellular Developmental Process Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Developmental Process T Cell Costimulation Regulation Of Multicellular Organismal Development Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Negative Regulation Of Axonogenesis Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Cell Junction Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen 1,4-alpha-glucan Branching Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona	None