EPHB3 and RNF186

Number of citations: 58 (PubMedID 33280498)
Data Source: BioGRID (enzymatic study)

		EPHB3	RNF186
Name		EPH receptor B3	ring finger protein 186
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Urogenital System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Axonal Fasciculation Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis	Protein Ubiquitination Protein K29-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Apoptotic Process In Response To Mitochondrial Fragmentation Regulation Of Autophagosome Assembly
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	None
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680 ) Nicotine dependence symptom count ( 25555482 ) Nose size ( 27182965 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Inflammatory bowel disease ( 28067908 ) Ulcerative colitis ( 19122664 20228799 23511034 28067908 )
Interacting Genes		14 interacting genes: AFDN CRK EFNB3 ERBB2 FBXO7 FYN GBE1 HPCAL1 HSF2BP LNX1 NFRKB RASA1 RNF186 RYK	8 interacting genes: EPHB2 EPHB3 HIVEP1 PBX3 SCAND1 SESN2 UBE2D2 UBE2H
Entrez ID		2049	54546
HPRD ID		03502	07885
Ensembl ID		ENSG00000182580	ENSG00000178828
Uniprot IDs		P54753	Q9NXI6
PDB IDs		3P1I 3ZFY 5L6O 5L6P	Not available
GO Terms Enriched among Interactors		Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Neuron Projection Guidance Axon Guidance Positive Regulation Of Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Reelin-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Protein Tyrosine Kinase Activity Regulation Of Cell Shape Positive Regulation Of Protein Targeting To Membrane Regulation Of Developmental Process Signaling Receptor Binding Regulation Of Protein Targeting To Membrane Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Projection Organization Phosphotyrosine Residue Binding Negative Regulation Of Immune System Process Cellular Developmental Process Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Developmental Process T Cell Costimulation Regulation Of Multicellular Organismal Development Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Negative Regulation Of Axonogenesis Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Cell Junction Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen 1,4-alpha-glucan Branching Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona	Axon Guidance Receptor Activity Urogenital System Development Corpus Callosum Development Dendritic Spine Development Retinal Ganglion Cell Axon Guidance Transmembrane-ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Dendritic Spine Morphogenesis Ephrin Receptor Activity Central Nervous System Projection Neuron Axonogenesis Dendritic Spine Organization Central Nervous System Neuron Axonogenesis Ubiquitin Conjugating Enzyme Activity Neuron Projection Organization Postsynapse Organization Neuron Recognition Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Polyubiquitination Protein Modification Process Positive Regulation Of Synapse Assembly Posterior Compartment Specification Anterior Compartment Pattern Formation Roof Of Mouth Development Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Sulfiredoxin Activity Positive Regulation Of Cell Junction Assembly Protein K48-linked Ubiquitination Vesicle-mediated Intercellular Transport Cell Recognition Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Tyrosine Kinase Activity Regulation Of Axonogenesis Compartment Pattern Specification ATP Binding Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Axonogenesis Dorsal Spinal Cord Development Protein Ubiquitination Positive Regulation Of Lipophagy Regulation Of Synapse Assembly Enzyme-linked Receptor Protein Signaling Pathway Oxidoreductase Activity, Acting On Peroxide As Acceptor Protein Modification By Small Protein Conjugation Postsynaptic Membrane Assembly L-leucine Binding Atg1/ULK1 Kinase Complex