EPHB3 and AFDN

Number of citations: 36 (PubMedID 9707552)
Data Source: BioGRID (pull down), HPRD (in vitro, two hybrid, in vivo)

		EPHB3	AFDN
Name		EPH receptor B3	afadin, adherens junction formation factor
Structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite Cell Projection	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Kinase Activity Transferase Activity	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Angiogenesis Urogenital System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Axonal Fasciculation Cell Migration Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of GTPase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Thymus Development Digestive Tract Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Roof Of Mouth Development Dendritic Spine Development Dendritic Spine Morphogenesis	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	None
Drugs		None	(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680 ) Nicotine dependence symptom count ( 25555482 ) Nose size ( 27182965 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906 )
Interacting Genes		14 interacting genes: AFDN CRK EFNB3 ERBB2 FBXO7 FYN GBE1 HPCAL1 HSF2BP LNX1 NFRKB RASA1 RNF186 RYK	39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		2049	4301
HPRD ID		03502	01164
Ensembl ID		ENSG00000182580	ENSG00000130396
Uniprot IDs		P54753	A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		3P1I 3ZFY 5L6O 5L6P	1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
GO Terms Enriched among Interactors		Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Neuron Projection Guidance Axon Guidance Positive Regulation Of Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Reelin-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Protein Tyrosine Kinase Activity Regulation Of Cell Shape Positive Regulation Of Protein Targeting To Membrane Regulation Of Developmental Process Signaling Receptor Binding Regulation Of Protein Targeting To Membrane Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Projection Organization Phosphotyrosine Residue Binding Negative Regulation Of Immune System Process Cellular Developmental Process Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Developmental Process T Cell Costimulation Regulation Of Multicellular Organismal Development Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Negative Regulation Of Axonogenesis Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Lymphocyte Activation Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Negative Regulation Of Apoptotic Process Cell Junction Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen 1,4-alpha-glucan Branching Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona	Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules