GPR42 and TM4SF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR42	TM4SF4
Description		G protein-coupled receptor 42	transmembrane 4 L six family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Tissue Regeneration
Pathways
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Gallstone disease ( 27094239 30504769) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31578528)
Interacting Genes		110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1	22 interacting genes: APH1B CD79A CLEC17A CMTM2 CREB3 ERGIC3 FATE1 FFAR2 GJB1 GJB4 GJB5 GLP1R GPR101 GPR37L1 GPR42 GPX8 KCNK5 LHFPL5 OPRM1 SLC10A6 TBXA2R TMEM14B
Entrez ID		2866	7104
HPRD ID		16033	07585
Ensembl ID		ENSG00000126251	ENSG00000169903
Uniprot IDs		A0A0K0PUY3 O15529	P48230
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion	Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity Gap Junction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Blood Pressure Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Negative Regulation Of Blood Pressure
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