GPR42 and ALOX5AP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR42	ALOX5AP
Description		G protein-coupled receptor 42	arachidonate 5-lipoxygenase activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Arachidonate Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Leukotriene Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification
Pathways			Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX)
Drugs			DG031 AM103 Fiboflapon Veliflapon MK-886
Diseases
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)
Interacting Genes		110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1	10 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B
Entrez ID		2866	241
HPRD ID		16033	04742
Ensembl ID		ENSG00000126251	ENSG00000132965
Uniprot IDs		A0A0K0PUY3 O15529	A0A087WW23 P20292
PDB IDs			2Q7M 2Q7R 6VGC 6VGI
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion	Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Biosynthetic Process Leukocyte Chemotaxis Leukotriene Metabolic Process Cell Chemotaxis Regulation Of Protein Secretion Long-chain Fatty Acid Biosynthetic Process Leukocyte Migration Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Nuclear Membrane Negative Regulation Of Endothelial Cell Proliferation Membrane Icosanoid Biosynthetic Process Nitrate Transmembrane Transporter Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Metformin Leukotriene A4 Metabolic Process Locomotion Leukotriene Production Involved In Inflammatory Response Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Positive Regulation Of Developmental Process Arachidonate 12(S)-lipoxygenase Activity Chemotaxis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport G Protein-coupled Receptor Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Protein Secretion Uracil Transmembrane Transport Thymine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Cellular Response To Morphine Soluble NSF Attachment Protein Activity SNARE Complex Disassembly
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