GPR42 and GYPC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPR42	GYPC
Description		G protein-coupled receptor 42	glycophorin C (Gerbich blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane Cortical Cytoskeleton
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Atrial fibrillation ( 29892015 30061737) Diastolic blood pressure ( 30224653) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Initial pursuit acceleration ( 29064472) Intelligence ( 22449649) Metabolite levels ( 23823483) Pelvic organ prolapse (moderate/severe) ( 26545240) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 31217584) Tea consumption ( 31046077)
Interacting Genes		110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1	13 interacting genes: ABHD16A AQP6 EPB41 GPR42 MPP1 PDIA3 PLPPR2 RHBDD1 SHISAL1 SLC10A6 TMEM14B TMEM88 TSPAN15
Entrez ID		2866	2995
HPRD ID		16033	00193
Ensembl ID		ENSG00000126251	ENSG00000136732
Uniprot IDs		A0A0K0PUY3 O15529	P04921
PDB IDs			2EJY
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Cortical Cytoskeleton Tapasin-ERp57 Complex Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport
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