ZNF408 and PDLIM4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		ZNF408	PDLIM4
Description		zinc finger protein 408	PDZ and LIM domain 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Stress Fiber Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Actin Cytoskeleton Membrane Z Disc Lamellipodium Early Endosome Membrane Early Endosome Lumen Filamentous Actin Recycling Endosome Lumen Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Actin Binding Protein Binding Protein Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Heart Development Actin Cytoskeleton Organization Muscle Structure Development Excitatory Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Femoral neck bone mineral density ( 29499414) Schizophrenia ( 29483656)	Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Height ( 28552196) Inflammatory bowel disease ( 23128233 28067908) Mosquito bite size ( 28199695) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		83 interacting genes: AEBP2 AEN APOBEC3C ATRN BAHD1 CALCOCO2 CCDC136 CEP70 CHAF1A CRELD1 CYSRT1 DDX56 DVL3 EXOSC2 FBLN2 FHL2 FHL5 FSD2 GIPC1 GPATCH2L HNRNPK HOXA5 HOXB9 ID3 KCTD9 KHDRBS3 KRT40 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP4-12 KRTAP5-9 LDOC1 LSM2 LZTS2 MDFI MID2 MIF MRRF MTUS2 NBPF19 NOTCH2NLA PDE4DIP PDLIM4 PICK1 PNMA2 PRAME PRNP PRPF31 PSTPIP1 RALY RALYL RBM10 RBMY1F RBMY1J SAP30BP SPRED1 SSX2IP THAP1 TLE5 TOP3B TRIM23 TRIM41 UBE2I UPF2 USP20 ZBTB26 ZBTB48 ZBTB8A ZBTB9 ZC4H2 ZNF212 ZNF317 ZNF330 ZNF331 ZNF473 ZNF526 ZNF764 ZNF792 ZNF837 ZRANB1	8 interacting genes: ABCA1 AMT FAM222B PTPN13 RBPMS SDCBP TRIP6 ZNF408
Entrez ID		79797	8572
HPRD ID		18338	04571
Ensembl ID		ENSG00000175213	ENSG00000131435
Uniprot IDs		B4DXY4 Q9H9D4	A0A0S2Z4N4 P50479
PDB IDs			2EEG 2V1W 4Q2O
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleus Protein Binding Zinc Ion Binding Intermediate Filament Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Keratin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex MRNA Processing Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Muramyl Dipeptide
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