ZNF408 and CRELD1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		ZNF408	CRELD1
Description		zinc finger protein 408	CRELD disulfide isomerase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Membrane Extracellular Matrix Synapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Isomerase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Endocardial Cushion Development Cardiac Septum Development
Pathways
Drugs
Diseases			Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Femoral neck bone mineral density ( 29499414) Schizophrenia ( 29483656)	Blood protein levels ( 30072576)
Interacting Genes		83 interacting genes: AEBP2 AEN APOBEC3C ATRN BAHD1 CALCOCO2 CCDC136 CEP70 CHAF1A CRELD1 CYSRT1 DDX56 DVL3 EXOSC2 FBLN2 FHL2 FHL5 FSD2 GIPC1 GPATCH2L HNRNPK HOXA5 HOXB9 ID3 KCTD9 KHDRBS3 KRT40 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP4-12 KRTAP5-9 LDOC1 LSM2 LZTS2 MDFI MID2 MIF MRRF MTUS2 NBPF19 NOTCH2NLA PDE4DIP PDLIM4 PICK1 PNMA2 PRAME PRNP PRPF31 PSTPIP1 RALY RALYL RBM10 RBMY1F RBMY1J SAP30BP SPRED1 SSX2IP THAP1 TLE5 TOP3B TRIM23 TRIM41 UBE2I UPF2 USP20 ZBTB26 ZBTB48 ZBTB8A ZBTB9 ZC4H2 ZNF212 ZNF317 ZNF330 ZNF331 ZNF473 ZNF526 ZNF764 ZNF792 ZNF837 ZRANB1	17 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HOXA1 HTR2C KAT5 MAP3K1 MTNR1B NUFIP2 POLA2 PTN SETDB1 SHANK3 ZNF408
Entrez ID		79797	78987
HPRD ID		18338	06206
Ensembl ID		ENSG00000175213	ENSG00000163703
Uniprot IDs		B4DXY4 Q9H9D4	A0A669KAV0 A0A669KBB3 A0A804HJJ0 A0A804HKP7 Q96HD1
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Nucleus Protein Binding Zinc Ion Binding Intermediate Filament Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Keratin Filament Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Spliceosomal Complex MRNA Processing Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Muramyl Dipeptide	Regulation Of Synapse Structural Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Hormone Secretion Auditory Behavior Cognition Regulation Of Circadian Rhythm Neuromuscular Process Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Memory Regulation Of Behavior Mechanosensory Behavior Regulation Of Circadian Sleep/wake Cycle Regulation Of Nervous System Process Positive Regulation Of Circadian Rhythm Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Binding Learning Regulation Of Peptide Hormone Secretion Regulation Of Cell Development Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Regulation Of Synaptic Plasticity Positive Regulation Of Cell Development Regulation Of Multicellular Organismal Process Negative Regulation Of Peptide Secretion Semicircular Canal Formation Regulation Of Lipid Biosynthetic Process Assembly Of Large Subunit Precursor Of Preribosome Histone H2AK5 Acetyltransferase Activity Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Neurogenesis Regulation Of Hormone Levels Ciliary Membrane Visual Behavior G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Synapse Negative Regulation Of Sequestering Of Calcium Ion Female Gamete Generation Regulation Of Progesterone Secretion Abducens Nerve Formation Optokinetic Behavior 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
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