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UBE2L3 and BRCA1
Number of citations of the paper that reports this interaction (PubMedID
12732733
)
41
Data Source:
HPRD
(in vitro)
UBE2L3
BRCA1
Description
ubiquitin conjugating enzyme E2 L3
BRCA1 DNA repair associated
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Gamma-tubulin Ring Complex
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Plasma Membrane
Nuclear Body
BRCA1-BARD1 Complex
Protein-containing Complex
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
DNA Repair Complex
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Transcription Cis-regulatory Region Binding
P53 Binding
DNA Binding
Damaged DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
RNA Polymerase Binding
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Biological Process
Protein Polyubiquitination
Regulation Of DNA-templated Transcription
Ubiquitin-dependent Protein Catabolic Process
Cell Population Proliferation
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Modification Process
Cell Cycle Phase Transition
Positive Regulation Of DNA-templated Transcription
Protein K11-linked Ubiquitination
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Protein Targeting To Mitochondrion
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Double-strand Break Repair
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
DNA Damage Response
Chromosome Segregation
Mitotic G2 DNA Damage Checkpoint Signaling
Centrosome Cycle
Sex-chromosome Dosage Compensation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Cell Growth
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Homologous Recombination
Chordate Embryonic Development
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of DNA Repair
Positive Regulation Of Angiogenesis
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Cell Cycle
Protein Autoubiquitination
Random Inactivation Of X Chromosome
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ionizing Radiation
Cellular Response To Indole-3-methanol
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
PINK1-PRKN Mediated Mitophagy
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation
Meiotic synapsis
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Neddylation
Transcriptional Regulation by E2F6
Meiotic recombination
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases
Ovarian cancer
Breast cancer
GWAS
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Ankylosing spondylitis (
23749187
)
Apolipoprotein A1 levels (
32203549
)
Celiac disease (
20190752
30572963
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Eosinophil percentage of white cells (
32888494
)
HDL cholesterol (
24097068
20686565
25961943
)
HDL cholesterol levels (
32203549
28334899
30698716
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hepatitis B (
24162738
)
High density lipoprotein cholesterol levels (
29403010
33339817
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lymphocyte count (
32888494
27863252
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
27863252
32888494
)
Mean corpuscular volume (
20139978
29403010
28017375
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
27863252
)
Non-albumin protein levels (
29403010
)
Optic disc size (
31809533
)
Psoriasis (
23143594
)
Red blood cell traits (
23222517
)
Red cell distribution width (
27863252
32888494
28957414
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Rheumatoid arthritis (
24390342
30423114
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Systemic lupus erythematosus (
21408207
23273568
26502338
27399966
28714469
19838193
19838195
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Total cholesterol levels (
30275531
)
Ulcerative colitis (
28067908
)
Aspartate aminotransferase levels (
33547301
)
Gynecologic disease (multivariate analysis) (
31488892
)
Menopause (age at onset) (
26414677
29773799
)
Monocyte percentage of white cells (
32888494
)
Ovarian cancer (
31488892
)
Ovarian cancer (MTAG) (
31488892
)
Interacting Genes
113 interacting genes:
ANKIB1
AREL1
ARIH1
ARIH2
ATXN3
BRAP
BRCA1
CBL
CBLB
CBLC
CCNB1IP1
CDC42
CDKN1B
CUL5
CUL9
DTX3
FBXO2
FOS
HACE1
HECTD1
HECTD2
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC3
HERC4
HERC6
HSPA4
HUWE1
IRF2BP1
ITCH
LIG4
LTN1
MAPK6
MDM2
MEX3A
MEX3C
MID1
MKRN2
MKRN3
MUL1
MYCBP2
NEDD4
NEDD4L
NFKBIA
NR3C1
OTUD3
PIAS1
PIAS2
PJA1
POLR2A
PRKN
PTEN
RBCK1
RBX1
RC3H1
RELA
RNF103
RNF111
RNF113B
RNF114
RNF125
RNF14
RNF144A
RNF144B
RNF150
RNF168
RNF170
RNF182
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF31
RNF7
RTF2
SMAD4
SMAD7
SMURF1
SMURF2
STUB1
TP53
TRAF6
TRAF7
TRIM13
TRIM21
TRIM23
TRIM25
TRIM28
TRIM31
TRIM39
TRIM55
TRIP12
UBA1
UBA5
UBA6
UBA7
UBASH3A
UBC
UBE3A
UBE3C
UBOX5
UBR4
UBR5
VPS11
WWP1
WWP2
XIAP
323 interacting genes:
ABL1
ABRAXAS1
ACACA
ACTG1
ACTN3
AKT1
ALDH1A1
ANKRD28
ANTXR1
AP1M1
APLP2
AR
ARNT
ASH2L
ATF1
ATM
ATP1B1
ATP1B3
ATR
ATRIP
AURKA
AURKC
BABAM1
BAP1
BARD1
BRAP
BRAT1
BRCA2
BRCC3
BRIP1
BRSK1
CABYR
CASP3
CATSPERT
CAVIN3
CBX1
CBX5
CCDC120
CCNA1
CCNA2
CCNB1
CCND1
CDC25C
CDK1
CDK2
CDK4
CDK7
CDKN2D
CEP57L1
CHEK1
CHEK2
CLSPN
CNRIP1
CNTLN
CNTN4
COL1A1
COMMD1
CREBBP
CRY2
CRYZL1
CSNK1D
CSNK2A1
CSNK2B
CSTF1
CTBP1
CTCFL
CTNNB1
CUBN
CWF19L2
DALRD3
DBF4
DCLRE1C
DCN
DDX24
DES
DHPS
DHX9
DNAJA1
DNAJA3
DNAJB1
DNHD1
DYNC1H1
DYNLT2B
E2F1
E2F4
EED
EIF3B
EIF4A2
EIF5B
ELK1
ELK4
ELOA
ENO1
EP300
ERCC5
ERO1B
ESR1
ETS1
ETV5
EZH2
FAM161A
FAM184A
FANCA
FANCD2
FBXO44
FHL2
FLI1
FLNA
FXR2
GCC1
GFI1B
GGN
GOLGA8DP
GTF3C4
GUSBP1
H2AC20
H2AC4
H2AX
H2BC3
H3C1
HDAC1
HDAC2
HECTD3
HGF
HIBADH
HIVEP1
HNRNPC
HNRNPD
HORMAD1
HSPA14
HSPA8
HSPD1
IFI16
INPP1
ITIH5
ITPR1
ITPRID2
JAK1
JAK2
JUN
JUNB
JUND
JUP
KAT5
KDM1A
KIF1B
KPNA2
KPNA6
LARP7
LCK
LCMT1
LDHC
LMNTD1
LMO4
LONRF1
MACROH2A1
MAN2C1
MAP3K1
MAP3K14
MAP3K3
MAP4K4
MARCKSL1
MDC1
MED1
MED21
MID2
MLH1
MNAT1
MSH2
MSH3
MSH6
MT-ND1
MYC
MYOZ1
NBN
NCOA2
NCOA3
NELFB
NFKB1
NFYA
NKAPL
NMI
NPC2
NRIP1
NSD2
NUFIP1
NUP153
OBSCN
PARG
PEG3
PEX5
PGR
PHF12
PIAS1
PIAS4
PIK3R1
PILRB
PIN1
PISD
POLB
POLR2A
POLR2H
POLR2K
POM121
POMGNT1
POU2F1
PPP1CA
PPP1CB
PPP1R13B
PPP2R5C
PREP
PRKAG3
PRKDC
PRMT1
PRPF3
PSAP
PSMA6
PSMA7
PSMD9
PSMG1
RACK1
RAD51
RANBP9
RB1
RBBP4
RBBP7
RBBP8
RBL1
RBL2
RCC1L
RELA
RFC1
RNF216
RPGRIP1
RPL31
RTKN2
RTL10
RUNX1T1
RWDD2B
RWDD4
SDK2
SETX
SKP2
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMC1A
SNRNP200
SNX3
SNX6
SOX30
SP1
SPATA4
SQSTM1
SSX2IP
STAC2
STAT1
STAT3
STAT5A
SUMO1
SYT6
TARS1
TATDN2
TCEA2
TCEANC
TEX101
THOC3
TLE4
TMPRSS12
TNS2
TOP1
TOP2A
TOP2B
TP53
TP53BP1
TPTE2
TRIM24
TRIM46
TRIM47
TRIM74
TRRAP
TSEN54
TSGA10IP
TUBA4A
TUBB
TUBG1
TULP2
TXLNA
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2J1
UBE2K
UBE2L3
UBE2N
UBE2T
UBE2W
UBE3A
UBXN1
USF2
USH2A
USP2
VCP
VHL
WDR6
WNT2B
WRN
XAF1
XIAP
XRCC1
XRCC5
YY1
ZNF280D
ZNF350
ZNF423
ZSCAN21
Entrez ID
7332
672
HPRD ID
04762
00218
Ensembl ID
ENSG00000185651
ENSG00000012048
Uniprot IDs
P68036
A0A0U1RRA9
A0A2R8Y7V5
A0A9Y1QPR4
A0A9Y1QPT7
A0A9Y1QPY6
A0A9Y1QQ47
A0A9Y1QQD3
A0A9Y1QQF1
A0A9Y1QQJ6
A0A9Y1QQK3
A0A9Y1QQK7
A0A9Y1VR53
A0A9Y1VVD0
A0A9Y1VVE2
B4DES0
C9IZW4
E7ENB7
E7EQW4
E7EUM2
H0Y850
H0Y8D8
P38398
PDB IDs
1C4Z
1FBV
3SQV
3SY2
4Q5E
4Q5H
5HPT
5TTE
5UDH
6CP2
6DJW
6DJX
6N13
6XXU
7B5L
7B5N
7OIK
7V8F
8EAZ
8EB0
1JM7
1JNX
1N5O
1OQA
1T15
1T29
1T2U
1T2V
1Y98
2ING
3COJ
3K0H
3K0K
3K15
3K16
3PXA
3PXB
3PXC
3PXD
3PXE
4IFI
4IGK
4JLU
4OFB
4U4A
4Y18
4Y2G
6G2I
7JZV
7LYB
8GRQ
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Activity
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Modification-dependent Protein Catabolic Process
Transferase Activity
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis
Macromolecule Metabolic Process
Catabolic Process
Zinc Ion Binding
Metal Ion Binding
Protein K48-linked Ubiquitination
Ubiquitin Ligase Complex
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Autoubiquitination
Cytoplasm
Negative Regulation Of Signal Transduction
Ubiquitin Conjugating Enzyme Binding
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein K63-linked Ubiquitination
Positive Regulation Of Catabolic Process
Intracellular Signal Transduction
Protein Monoubiquitination
Cellular Response To Stress
Regulation Of Signal Transduction
Response To Stress
Cytosol
Intracellular Receptor Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Protein Catabolic Process
Ubiquitin-ubiquitin Ligase Activity
Regulation Of Post-translational Protein Modification
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Nucleus
DNA Damage Response
Nucleic Acid Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Double-strand Break Repair
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle Phase Transition
Response To Ionizing Radiation
Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
DNA Damage Checkpoint Signaling
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Enzyme Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Chromosome, Telomeric Region
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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