UBE2L3 and CCNB1IP1

Number of citations of the paper that reports this interaction (PMID 12612082)
15

Data Source:
HPRD (two hybrid)

		UBE2L3	CCNB1IP1
Gene Name		ubiquitin-conjugating enzyme E2L 3	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Extracellular Vesicular Exosome	Synaptonemal Complex
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus	Blastocyst Formation Reciprocal Meiotic Recombination Spermatid Development Protein Ubiquitination Chiasma Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) HDL cholesterol ( 20686565) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 21408207 19838193)
Protein-Protein Interactions		64 interactors: ARIH1 ARIH2 ATXN3 BRCA1 CBL CBLC CCNB1IP1 CUL9 DTX3 FBXO2 FOS HACE1 HERC3 HSPA4 HUWE1 ITCH LIG4 MAPK6 MDM2 MID1 MKRN3 MUL1 NEDD4 NEDD4L NFKBIA NR3C1 PARK2 PJA1 POLR2A PTEN RAD23A RBCK1 RBX1 RELA RNF103 RNF113B RNF125 RNF144A RNF144B RNF19A RNF2 RNF216 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TRAF6 TRAF7 TRIM21 TRIM28 TRIM39 TRIP12 UBA1 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR5 WWP1 WWP2	9 interactors: APP CCNB1 EPM2AIP1 KEAP1 KRT15 NF2 PRKAA2 UBC UBE2L3
Entrez ID		7332	57820
HPRD ID		04762	07000
Ensembl ID		ENSG00000185651	ENSG00000100814
Uniprot IDs		P68036	Q9NPC3
PDB IDs		1C4Z 1FBV 3SQV 3SY2
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Polyubiquitination Proteolysis Protein Metabolic Process Catabolic Process Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Viral Process Regulation Of Protein Catabolic Process Cellular Response To Organic Substance Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Protein K48-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Cellular Response To Stress Metabolic Process Protein Autoubiquitination Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Organic Substance Response To Growth Factor Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cytokine Production Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Positive Regulation Of Protein Catabolic Process	Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Histone-serine Phosphorylation Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Catalytic Activity Regulation Of Proteolysis Response To Organic Substance Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Kinase Activity Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Histone Phosphorylation Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Catabolic Process Regulation Of Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Response To Organic Substance Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Cell Cycle Process Regulation Of Gene Expression Histone H3-S10 Phosphorylation Involved In Chromosome Condensation Response To DDT Cellular Response To Iron(III) Ion Regulation Of Mitotic Cell Cycle
Tagcloud ?		2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Difference) ?		2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants
Tagcloud (Intersection) ?