UBE2L3 and ATXN3

Number of citations of the paper that reports this interaction (PubMedID 22081612)
36

Data Source:
BioGRID (pull down)

		UBE2L3	ATXN3
Description		ubiquitin conjugating enzyme E2 L3	ataxin 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Matrix Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body Synapse
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Protein Polyubiquitination Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Cell Cycle Phase Transition Positive Regulation Of DNA-templated Transcription Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Protein Targeting To Mitochondrion	Microtubule Cytoskeleton Organization Cytoplasmic Translation Nucleotide-excision Repair Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Chemical Synaptic Transmission Nervous System Development Cellular Response To Starvation Regulation Of Cell-substrate Adhesion Protein Deubiquitination Actin Cytoskeleton Organization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Exploration Behavior TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Josephin domain DUBs FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Celiac disease ( 20190752 30572963 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 24097068 20686565 25961943) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hepatitis B ( 24162738) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 20139978 29403010 28017375 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Optic disc size ( 31809533) Psoriasis ( 23143594) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 21408207 23273568 26502338 27399966 28714469 19838193 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Total cholesterol levels ( 30275531) Ulcerative colitis ( 28067908)	Amyotrophic lateral sclerosis ( 29566793) Coronary artery calcification ( 23870195) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Height ( 18391950 18391951) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Orofacial clefts ( 22419666) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		113 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDC42 CDKN1B CUL5 CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH LIG4 LTN1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN2 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 OTUD3 PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RBCK1 RBX1 RC3H1 RELA RNF103 RNF111 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF182 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TP53 TRAF6 TRAF7 TRIM13 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WWP1 WWP2 XIAP	55 interacting genes: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 CAPN1 CAPN2 CASP1 CDKN1A CHEK1 CSNK2B DNM2 EWSR1 GABARAP GSK3B KAT2B KPNA2 MAP1LC3A MAP1LC3C MAP3K1 MKNK1 NCOR1 NEDD8 PHAF1 PICK1 PRKN PSMD7 RAD23A RAD23B RFFL RPS6KA1 SMURF1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2D3 UBE2L3 UBE2S UBE2W UBE4B UBQLN1 USP21 VCP WWP2
Entrez ID		7332	4287
HPRD ID		04762	06131
Ensembl ID		ENSG00000185651	ENSG00000066427
Uniprot IDs		P68036	A0A0A0MS38 C9JQV6 P54252
PDB IDs		1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13 6XXU 7B5L 7B5N 7OIK 7V8F 8EAZ 8EB0	1YZB 2AGA 2DOS 2JRI 2KLZ 4WTH 4YS9
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Zinc Ion Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Cytoplasm Negative Regulation Of Signal Transduction Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K63-linked Ubiquitination Positive Regulation Of Catabolic Process Intracellular Signal Transduction Protein Monoubiquitination Cellular Response To Stress Regulation Of Signal Transduction Response To Stress Cytosol Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cytosol Post-translational Protein Modification Cytoplasm Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Autophagy Positive Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding Protein K63-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Stress Ubiquitin Protein Ligase Activity Nucleus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Mitophagy Macroautophagy Regulation Of Programmed Cell Death Protein Autoubiquitination
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