UBE2L3 and CDKN1B

Number of citations: 84 (PubMedID 30113882)
Data Source: BioGRID (enzymatic study)

		UBE2L3	CDKN1B
Name		ubiquitin conjugating enzyme E2 L3	cyclin dependent kinase inhibitor 1B
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cilium Cul4A-RING E3 Ubiquitin Ligase Complex Ciliary Basal Body
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin-dependent Protein Kinase Regulator Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Protein Polyubiquitination Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Cell Cycle Phase Transition Positive Regulation Of DNA-templated Transcription Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Protein Targeting To Mitochondrion	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Placenta Development Potassium Ion Transport Apoptotic Process Regulation Of Exit From Mitosis Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Programmed Cell Death Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Negative Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Negative Regulation Of DNA-templated Transcription Negative Regulation Of Growth Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Nuclear Export Regulation Of Cell Cycle Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Senescence Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Epithelial Cell Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Diseases		None	Prostate cancer
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Ankylosing spondylitis ( 23749187 ) Apolipoprotein A1 levels ( 32203549 ) Celiac disease ( 20190752 30572963 22057235 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Eosinophil percentage of white cells ( 32888494 ) HDL cholesterol ( 24097068 20686565 25961943 ) HDL cholesterol levels ( 32203549 28334899 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hepatitis B ( 24162738 ) High density lipoprotein cholesterol levels ( 29403010 33339817 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Inflammatory bowel disease ( 28067908 23128233 ) Intraocular pressure ( 29617998 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 20139978 29403010 28017375 32888494 27863252 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Non-albumin protein levels ( 29403010 ) Optic disc size ( 31809533 ) Psoriasis ( 23143594 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 32888494 28957414 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 32888494 27863252 ) Rheumatoid arthritis ( 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Systemic lupus erythematosus ( 21408207 23273568 26502338 27399966 28714469 19838193 19838195 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Total cholesterol levels ( 30275531 ) Ulcerative colitis ( 28067908 )	Appendicular lean mass ( 33097823 ) Brain morphology (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30487518 ) Mean arterial pressure ( 29403010 30487518 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Plateletcrit ( 32888494 ) Prostate cancer ( 29892016 31562322 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 23273568 33272962 ) Systolic blood pressure ( 30487518 ) Type 2 diabetes ( 30297969 )
Interacting Genes		113 interacting genes: ANKIB1 AREL1 ARIH1 ARIH2 ATXN3 BRAP BRCA1 CBL CBLB CBLC CCNB1IP1 CDC42 CDKN1B CUL5 CUL9 DTX3 FBXO2 FOS HACE1 HECTD1 HECTD2 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC3 HERC4 HERC6 HSPA4 HUWE1 IRF2BP1 ITCH LIG4 LTN1 MAPK6 MDM2 MEX3A MEX3C MID1 MKRN2 MKRN3 MUL1 MYCBP2 NEDD4 NEDD4L NFKBIA NR3C1 OTUD3 PIAS1 PIAS2 PJA1 POLR2A PRKN PTEN RBCK1 RBX1 RC3H1 RELA RNF103 RNF111 RNF113B RNF114 RNF125 RNF14 RNF144A RNF144B RNF150 RNF168 RNF170 RNF182 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF31 RNF7 RTF2 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TP53 TRAF6 TRAF7 TRIM13 TRIM21 TRIM23 TRIM25 TRIM28 TRIM31 TRIM39 TRIM55 TRIP12 UBA1 UBA5 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR4 UBR5 VPS11 WWP1 WWP2 XIAP	70 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RCHY1 RNF123 RNF6 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2L3 UBE3A UCHL1 WWP1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		7332	1027
HPRD ID		04762	02867
Ensembl ID		ENSG00000185651	ENSG00000111276
Uniprot IDs		P68036	P46527 Q6I9V6
PDB IDs		1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13 6XXU 7B5L 7B5N 7OIK 7V8F 8EAZ 8EB0	1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R 7OR8 7ORG 7ORH 7ORS 7ORT 8BYA 8BYL 8BZO
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Zinc Ion Binding Metal Ion Binding Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Cytoplasm Negative Regulation Of Signal Transduction Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K63-linked Ubiquitination Positive Regulation Of Catabolic Process Intracellular Signal Transduction Protein Monoubiquitination Cellular Response To Stress Regulation Of Signal Transduction Response To Stress Cytosol Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Nucleus Cell Cycle Phase Transition Nucleoplasm Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cytosol Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Metabolic Process Macromolecule Catabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Cell Cycle Proteolysis Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Catabolic Process Protein Polyubiquitination Protein Localization To Nucleus Transferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity NLS-bearing Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of DNA Metabolic Process Protein Import Into Nucleus Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Kinase Binding Phosphoserine Residue Binding