MEP1B and PYY

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		MEP1B	PYY
Gene Name		meprin A, beta	peptide YY
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	G-protein Coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding
	Biological Process	Proteolysis Inflammatory Response Digestion Toxin Transport	Movement Of Cell Or Subcellular Component Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Digestion Feeding Behavior Cell Proliferation Regulation Of Appetite Eating Behavior
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		12 interactors: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT	5 interactors: MEP1B NPY1R NPY2R NPY4R NPY5R
Entrez ID		4225	5697
HPRD ID		02667	02869
Ensembl ID		ENSG00000141434	ENSG00000131096
Uniprot IDs		J3QKX5 Q16820	P10082
PDB IDs		4GWM 4GWN	2DEZ 2DF0 2L60
Enriched GO Terms of Interacting Partners?		Feeding Behavior Regulation Of Appetite Digestion G-protein Coupled Receptor Signaling Pathway Behavior Negative Regulation Of Glial Cell Apoptotic Process Neuropeptide Signaling Pathway Regulation Of Platelet Aggregation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Response To Food Response To Nutrient Levels Regulation Of Protein Binding Response To Extracellular Stimulus Response To Stimulus Regulation Of Cellular Ketone Metabolic Process Regulation Of Platelet Activation Eating Behavior Platelet Activation Response To External Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Body Fluid Levels Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Binding Activation Of Phospholipase C Activity Cell Proliferation Response To Glucagon Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process	Neuropeptide Signaling Pathway Outflow Tract Morphogenesis Feeding Behavior Synaptic Transmission Behavior Cardiac Left Ventricle Morphogenesis Heart Morphogenesis Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cardiac Ventricle Morphogenesis Heart Development Cardiac Ventricle Development Generation Of Ovulation Cycle Rhythm Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Anion Transport Cardiac Chamber Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cardiovascular System Development Negative Regulation Of Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Organ Morphogenesis Locomotory Behavior Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of Glutamate Secretion Cell Surface Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Excitatory Postsynaptic Membrane Potential Blood Circulation Regulation Of Synaptic Transmission Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Catecholamine Secretion Regulation Of Glutamate Secretion Negative Regulation Of Transport Negative Regulation Of Membrane Potential Regulation Of Feeding Behavior Negative Regulation Of Neurological System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Nitric Oxide Mediated Signal Transduction Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Dopamine Secretion Response To Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Smooth Muscle Contraction Negative Regulation Of CAMP Biosynthetic Process
Tagcloud ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand
Tagcloud (Difference) ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand
Tagcloud (Intersection) ?