MEP1B and PYY

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1B	PYY
Description		meprin A subunit beta	peptide YY
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Meprin A Complex	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Proteolysis Inflammatory Response	Neuropeptide Signaling Pathway Feeding Behavior Intestinal Epithelial Cell Differentiation
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)	Blood protein levels ( 30072576) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Pulse pressure ( 28135244) Response to taxane treatment (paclitaxel) ( 23006423) Triglyceride levels ( 32203549)
Interacting Genes		13 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT TSPAN8	6 interacting genes: MEP1B NPY1R NPY2R NPY4R NPY5R SGTA
Entrez ID		4225	5697
HPRD ID		02667	02869
Ensembl ID		ENSG00000141434	ENSG00000131096
Uniprot IDs		J3QKX5 Q16820	P10082
PDB IDs		4GWM 4GWN 7AQ1 7AUW	2DEZ 2DF0 2L60 2NA5 7RT9 7YON
Enriched GO Terms of Interacting Partners?		Hormone Activity Neuropeptide Hormone Activity G Protein-coupled Receptor Signaling Pathway Extracellular Space Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Y Receptor Binding Extracellular Region Positive Regulation Of Hormone Secretion Signaling Receptor Binding Signal Transduction Regulation Of Peptide Hormone Secretion Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Hormone Levels Cellular Response To Glucagon Stimulus Intestinal Epithelial Cell Differentiation Regulation Of Hormone Secretion Regulation Of Secretion By Cell Regulation Of Body Fluid Levels Regulation Of Transport Positive Regulation Of Secretion By Cell Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Secretion Positive Regulation Of Secretion Response To Glucagon Receptor Ligand Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gluconeogenesis Regulation Of Appetite Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Positive Regulation Of Transport Regulation Of Protein Transport Cellular Response To Peptide Hormone Stimulus Peptidyl-serine Phosphorylation Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Glucose Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Gluconeogenesis Short-day Photoperiodism Negative Regulation Of Coagulation	Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Binding Outflow Tract Morphogenesis G Protein-coupled Receptor Activity Synaptic Signaling Via Neuropeptide Cardiac Left Ventricle Morphogenesis Signaling Cell Communication Cardiac Ventricle Morphogenesis G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Neuron Projection Regulation Of Amine Transport Feeding Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Generation Of Ovulation Cycle Rhythm Meprin A Complex TRC Complex Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission, GABAergic BAT3 Complex Binding Negative Regulation Of Secretion Negative Regulation Of Glutamate Secretion Locomotory Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of ERAD Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Presynapse Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Membrane Positive Regulation Of Catecholamine Secretion Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Amino Acid Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Tail-anchored Membrane Protein Insertion Into ER Membrane Plasma Membrane Synaptic Signaling Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Nitric Oxide Mediated Signal Transduction
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