MEP1B and GAST

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1B	GAST
Description		meprin A subunit beta	gastrin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Meprin A Complex	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Hormone Activity Protein Binding
	Biological Process	Proteolysis Inflammatory Response	Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Food
Pathways			G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Oxetacaine
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)
Interacting Genes		13 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT TSPAN8	24 interacting genes: AQP6 AQP9 ASPH BCL2L13 CISD2 CP CPE CREB3L1 CYB5R3 ERGIC3 FAM209A GOLM1 GPR152 KIR2DL3 KRT34 LHFPL2 MEP1B MMD MME MUC1 PDZK1IP1 PLP1 SLC10A1 TMEM52B
Entrez ID		4225	2520
HPRD ID		02667	00671
Ensembl ID		ENSG00000141434	ENSG00000184502
Uniprot IDs		J3QKX5 Q16820	A0A0E3VY36 P01350
PDB IDs		4GWM 4GWN 7AQ1 7AUW	5WRJ 7F8V 7F8W 7XOW
Enriched GO Terms of Interacting Partners?		Hormone Activity Neuropeptide Hormone Activity G Protein-coupled Receptor Signaling Pathway Extracellular Space Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Y Receptor Binding Extracellular Region Positive Regulation Of Hormone Secretion Signaling Receptor Binding Signal Transduction Regulation Of Peptide Hormone Secretion Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Hormone Levels Cellular Response To Glucagon Stimulus Intestinal Epithelial Cell Differentiation Regulation Of Hormone Secretion Regulation Of Secretion By Cell Regulation Of Body Fluid Levels Regulation Of Transport Positive Regulation Of Secretion By Cell Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Secretion Positive Regulation Of Secretion Response To Glucagon Receptor Ligand Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gluconeogenesis Regulation Of Appetite Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Positive Regulation Of Transport Regulation Of Protein Transport Cellular Response To Peptide Hormone Stimulus Peptidyl-serine Phosphorylation Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Glucose Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Gluconeogenesis Short-day Photoperiodism Negative Regulation Of Coagulation	Membrane
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