MEP1B and GRP

Number of citations of the paper that reports this interaction (PMID 11278902)
30

Data Source:
HPRD (in vitro)

		MEP1B	GRP
Gene Name		meprin A, beta	gastrin-releasing peptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Receptor Binding Neuropeptide Hormone Activity
	Biological Process	Proteolysis Inflammatory Response Digestion Toxin Transport	Signal Transduction Neuropeptide Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT	4 interactors: DPP4 GRPR MEP1A MEP1B
Entrez ID		4225	2922
HPRD ID		02667	08845
Ensembl ID		ENSG00000141434	ENSG00000134443
Uniprot IDs		J3QKX5 Q16820	P07492
PDB IDs		4GWM 4GWN
Enriched GO Terms of Interacting Partners?		Feeding Behavior Regulation Of Appetite Digestion G-protein Coupled Receptor Signaling Pathway Behavior Negative Regulation Of Glial Cell Apoptotic Process Neuropeptide Signaling Pathway Regulation Of Platelet Aggregation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Response To Food Response To Nutrient Levels Regulation Of Protein Binding Response To Extracellular Stimulus Response To Stimulus Regulation Of Cellular Ketone Metabolic Process Regulation Of Platelet Activation Eating Behavior Platelet Activation Response To External Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Body Fluid Levels Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Binding Activation Of Phospholipase C Activity Cell Proliferation Response To Glucagon Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Apoptotic Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process	Digestion Bombesin Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Extracellular Matrix Organization Proteolysis Regulation Of Cell-cell Adhesion Mediated By Integrin
Tagcloud ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	activators arsenite cations chaperones chemicals coordinate coupling cycling describing emphasized grp78 grps homeostatic hsp hsps integrative loading misfolding mobilizing modeled oxidants pertaining processing relates relating relationships thiol translation trigger
Tagcloud (Difference) ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 lgals1 lgals3bp maged1 metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	activators arsenite cations chaperones chemicals coordinate coupling cycling describing emphasized grp78 grps homeostatic hsp hsps integrative loading misfolding mobilizing modeled oxidants pertaining processing relates relating relationships thiol translation trigger
Tagcloud (Intersection) ?