PYY and NPY1R

Number of citations of the paper that reports this interaction (PubMedID 12665544)
0

Data Source:
HPRD (in vivo)

		PYY	NPY1R
Description		peptide YY	neuropeptide Y receptor Y1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane Neuron Projection
	Molecular Function	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding Neuropeptide Receptor Activity Neuropeptide Binding
	Biological Process	Neuropeptide Signaling Pathway Feeding Behavior Intestinal Epithelial Cell Differentiation	Outflow Tract Morphogenesis Glucose Metabolic Process Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotory Behavior Feeding Behavior Regulation Of Blood Pressure Sensory Perception Of Pain Signaling Regulation Of Multicellular Organism Growth
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Peptide YY (3-36)
Diseases
GWAS		Blood protein levels ( 30072576) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Pulse pressure ( 28135244) Response to taxane treatment (paclitaxel) ( 23006423) Triglyceride levels ( 32203549)	Daytime nap ( 33568662) Erythrocyte cadmium concentration ( 27005419) Lung cancer ( 28604730) Metabolite levels ( 23823483) Triglyceride levels ( 30108155)
Interacting Genes		6 interacting genes: MEP1B NPY1R NPY2R NPY4R NPY5R SGTA	4 interacting genes: ATP13A2 LSM7 NPY PYY
Entrez ID		5697	4886
HPRD ID		02869	01215
Ensembl ID		ENSG00000131096	ENSG00000164128
Uniprot IDs		P10082	P25929
PDB IDs		2DEZ 2DF0 2L60 2NA5 7RT9 7YON	5ZBQ 7VGX 7X9A 8K6M 8K6O
Enriched GO Terms of Interacting Partners?		Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Signaling Pathway Neuropeptide Binding Outflow Tract Morphogenesis G Protein-coupled Receptor Activity Synaptic Signaling Via Neuropeptide Cardiac Left Ventricle Morphogenesis Signaling Cell Communication Cardiac Ventricle Morphogenesis G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Neuron Projection Regulation Of Amine Transport Feeding Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Generation Of Ovulation Cycle Rhythm Meprin A Complex TRC Complex Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission, GABAergic BAT3 Complex Binding Negative Regulation Of Secretion Negative Regulation Of Glutamate Secretion Locomotory Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of ERAD Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Presynapse Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Membrane Positive Regulation Of Catecholamine Secretion Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Amino Acid Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Tail-anchored Membrane Protein Insertion Into ER Membrane Plasma Membrane Synaptic Signaling Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Nitric Oxide Mediated Signal Transduction	Neuropeptide Y Receptor Binding Intestinal Epithelial Cell Differentiation Neuropeptide Hormone Activity G Protein-coupled Receptor Binding Neuropeptide Signaling Pathway Short-day Photoperiodism Feeding Behavior Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Hormone Activity Regulation Of Nerve Growth Factor Production Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Regulation Of Exocytosis Intracellular Calcium Ion Homeostasis Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Calcium Ion Homeostasis Extracellular Vesicle Biogenesis Spermine Transport P-type Ion Transporter Activity P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Lsm1-7-Pat1 Complex Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Spliceosomal Tri-snRNP Complex Polyamine Transmembrane Transport Lsm2-8 Complex Regulation Of Eating Behavior Regulation Of Chaperone-mediated Autophagy Synaptic Signaling Via Neuropeptide Cellular Response To Manganese Ion U6 SnRNP Monocyte Activation Adult Feeding Behavior Antifungal Humoral Response Positive Regulation Of Feeding Behavior ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Intracellular Monoatomic Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Epithelial Cell Differentiation Response To Manganese Ion Autophagosome-lysosome Fusion
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