PYY and NPY1R

Number of citations of the paper that reports this interaction (PMID 12665544)
12

Data Source:
HPRD (in vivo)

		PYY	NPY1R
Gene Name		peptide YY	neuropeptide Y receptor Y1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Y Receptor Activity Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Digestion Feeding Behavior Cell Proliferation Regulation Of Appetite Eating Behavior	Outflow Tract Morphogenesis Glucose Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotory Behavior Feeding Behavior Regulation Of Blood Pressure Sensory Perception Of Pain Regulation Of Multicellular Organism Growth
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		5 interactors: MEP1B NPY1R NPY2R NPY4R NPY5R	4 interactors: ATP13A2 LSM7 NPY PYY
Entrez ID		5697	4886
HPRD ID		02869	01215
Ensembl ID		ENSG00000131096	ENSG00000164128
Uniprot IDs		P10082	P25929
PDB IDs		2DEZ 2DF0 2L60	2F1U 2IIL
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Outflow Tract Morphogenesis Feeding Behavior Synaptic Transmission Behavior Cardiac Left Ventricle Morphogenesis Heart Morphogenesis Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cardiac Ventricle Morphogenesis Heart Development Cardiac Ventricle Development Generation Of Ovulation Cycle Rhythm Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Anion Transport Cardiac Chamber Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cardiovascular System Development Negative Regulation Of Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Organ Morphogenesis Locomotory Behavior Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of Glutamate Secretion Cell Surface Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Excitatory Postsynaptic Membrane Potential Blood Circulation Regulation Of Synaptic Transmission Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Catecholamine Secretion Regulation Of Glutamate Secretion Negative Regulation Of Transport Negative Regulation Of Membrane Potential Regulation Of Feeding Behavior Negative Regulation Of Neurological System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Nitric Oxide Mediated Signal Transduction Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Dopamine Secretion Response To Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Smooth Muscle Contraction Negative Regulation Of CAMP Biosynthetic Process	Regulation Of Appetite Neuropeptide Signaling Pathway Feeding Behavior Digestion Cellular Response To Manganese Ion Positive Regulation Of Appetite Adult Feeding Behavior Response To Nutrient Levels Response To Extracellular Stimulus Response To Manganese Ion Regulation Of Response To Food Behavior Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Eating Behavior Cell Proliferation Cell-cell Signaling Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Tagcloud ?		antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand	able additionally anatomy breast circulating clinicopathological correlate detect digital displayer estrogen evaluate lymph marker metastasis nested neuropeptide node polymerase positively predict progesterone project serve shorter significance tool
Tagcloud (Difference) ?		antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand	able additionally anatomy breast circulating clinicopathological correlate detect digital displayer estrogen evaluate lymph marker metastasis nested neuropeptide node polymerase positively predict progesterone project serve shorter significance tool
Tagcloud (Intersection) ?