MEP1B and CCK

Number of citations of the paper that reports this interaction (PubMedID 11278902)
0

Data Source:
HPRD (in vitro)

		MEP1B	CCK
Description		meprin A subunit beta	cholecystokinin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Meprin A Complex	Extracellular Region Extracellular Space Axon
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Proteolysis Inflammatory Response	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Camostat
Diseases
GWAS		Metabolite levels ( 23823483) TRAIL levels ( 27989323)	Adult body size ( 32376654) Body mass index ( 24348519 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)
Interacting Genes		13 interacting genes: CCK FN1 GAST GCG GRP MEP1A NPY OS9 PRKACA PRKCD PYY SCT TSPAN8	7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
Entrez ID		4225	885
HPRD ID		02667	00321
Ensembl ID		ENSG00000141434	ENSG00000187094
Uniprot IDs		J3QKX5 Q16820	P06307 Q6FG82
PDB IDs		4GWM 4GWN 7AQ1 7AUW	7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK
Enriched GO Terms of Interacting Partners?		Hormone Activity Neuropeptide Hormone Activity G Protein-coupled Receptor Signaling Pathway Extracellular Space Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Y Receptor Binding Extracellular Region Positive Regulation Of Hormone Secretion Signaling Receptor Binding Signal Transduction Regulation Of Peptide Hormone Secretion Regulation Of Biological Quality G Protein-coupled Receptor Binding Regulation Of Hormone Levels Cellular Response To Glucagon Stimulus Intestinal Epithelial Cell Differentiation Regulation Of Hormone Secretion Regulation Of Secretion By Cell Regulation Of Body Fluid Levels Regulation Of Transport Positive Regulation Of Secretion By Cell Neuropeptide Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Secretion Positive Regulation Of Secretion Response To Glucagon Receptor Ligand Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Gluconeogenesis Regulation Of Appetite Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Behavior Positive Regulation Of Transport Regulation Of Protein Transport Cellular Response To Peptide Hormone Stimulus Peptidyl-serine Phosphorylation Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Glucose Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Gluconeogenesis Short-day Photoperiodism Negative Regulation Of Coagulation	Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity
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