PYY and NPY4R

Number of citations of the paper that reports this interaction (PMID 7493937)
19

Data Source:
HPRD (in vitro)

		PYY	NPY4R
Gene Name		peptide YY	neuropeptide Y receptor Y4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding	Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity G-protein Coupled Receptor Activity Peptide Binding
	Biological Process	Movement Of Cell Or Subcellular Component Cytoskeleton Organization G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Digestion Feeding Behavior Cell Proliferation Regulation Of Appetite Eating Behavior	G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Digestion Feeding Behavior Blood Circulation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		5 interactors: MEP1B NPY1R NPY2R NPY4R NPY5R	3 interactors: NPY PPY PYY
Entrez ID		5697	5540
HPRD ID		02869	03476
Ensembl ID		ENSG00000131096	ENSG00000204174
Uniprot IDs		P10082	P50391
PDB IDs		2DEZ 2DF0 2L60	2IK5
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Outflow Tract Morphogenesis Feeding Behavior Synaptic Transmission Behavior Cardiac Left Ventricle Morphogenesis Heart Morphogenesis Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cardiac Ventricle Morphogenesis Heart Development Cardiac Ventricle Development Generation Of Ovulation Cycle Rhythm Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Anion Transport Cardiac Chamber Development G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cardiovascular System Development Negative Regulation Of Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Organ Morphogenesis Locomotory Behavior Positive Regulation Of Dopamine Secretion Negative Regulation Of Feeding Behavior Negative Regulation Of Glutamate Secretion Cell Surface Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Excitatory Postsynaptic Membrane Potential Blood Circulation Regulation Of Synaptic Transmission Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Catecholamine Secretion Regulation Of Glutamate Secretion Negative Regulation Of Transport Negative Regulation Of Membrane Potential Regulation Of Feeding Behavior Negative Regulation Of Neurological System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Nitric Oxide Mediated Signal Transduction Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm Regulation Of Dopamine Secretion Response To Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Smooth Muscle Contraction Negative Regulation Of CAMP Biosynthetic Process	Regulation Of Appetite Neuropeptide Signaling Pathway Feeding Behavior Digestion Response To Nutrient Levels Response To Extracellular Stimulus Behavior Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Response To External Stimulus Positive Regulation Of Appetite Adult Feeding Behavior Cell Surface Receptor Signaling Pathway Regulation Of Response To Food Cell Proliferation Eating Behavior Signal Transduction Movement Of Cell Or Subcellular Component Signaling Central Nervous System Neuron Development Cell Communication Protein Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Tagcloud ?		antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		antiperoxidase antiserum bile bombesin charcoal coated dextran granules hormonal ileum immunohistochemically intraduodenal iv oleate pap peroxidase pg pmol pole rabbits radioimmunoassay raised ria rose secretory terminate triglyceride zealand	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?